Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.36 |
| ▸ | CTSA | P10619 | 2/20 | 0.33 |
| ▸ | MAT2A | P31153 | 1/20 | 0.33 |
| ▸ | TACR3 | P29371 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 3/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | RORB | Q92753 | 1/20 | 0.32 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | FNTA | P49354 | 1/20 | 0.32 |
| ▸ | FNTB | P49356 | 1/20 | 0.32 |
| ▸ | GUSB | P08236 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6010423 | 0.80 | LTB4R (0.38) | LTB4RAURKAAURKBNR1I3MAT2A | |
| SCHEMBL6009561 | 0.79 | FNTA (0.49) | FNTAFNTB | |
| SCHEMBL5549184 | 0.77 | LTB4R (0.42) | LTB4RAURKAAURKBNR1I3RORC | |
| SCHEMBL5657044 | 0.75 | AURKA (0.35) | LTB4RAURKAAURKBNR1I3CNR2 | |
| SCHEMBL1757872 | 0.74 | MEN1 (0.49) | LTB4RAURKAAURKBNR1I3MAT2A | |
| SCHEMBL6170916 | 0.73 | FNTA (0.55) | KMT2AFNTAFNTB | |
| SCHEMBL13333684 | 0.72 | LTB4R (0.37) | LTB4RAURKAAURKBNR1I3CTSA | |
| SCHEMBL5545677 | 0.71 | LTB4R (0.44) | LTB4RAURKAAURKBNR1I3MAT2A | |
| SCHEMBL5656596 | 0.71 | LTB4R (0.46) | LTB4RAURKAAURKBNR1I3MAT2A | |
| SCHEMBL25652640 | 0.70 | PTGS2 (0.35) | LTB4RAURKAAURKBRORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7196094-B2 | Farnesyl transferase inhibiting 6-heterocyclylmethyl quinoline and quinazoline derivatives | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-03-27 | — | — | US | disclosed |
| EP-1322650-A2 | FARNESYL TRANSFERASE INHIBITING 6-HETEROCYCLYLMETHYL QUINOLINE AND QUINAZOLINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002024686-A2 | FARNESYL TRANSFERASE INHIBITING 6-HETEROCYCLYLMETHYL QUINOLINE AND QUINAZOLINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2002-03-28 | — | — | WO | disclosed |