Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.79 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.70 |
| ▸ | PTGS2 | P35354 | 10/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.62 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.62 |
| ▸ | HTR1A | P08908 | 1/20 | 0.62 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.62 |
| ▸ | MC4R | P32245 | 1/20 | 0.62 |
| ▸ | GSK3B | P49841 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5549767 | 1.00 | KMT2A (0.79) | KMT2APTGS1PTGS2ALDH1A1ABCB11 | |
| SCHEMBL31349181 | 0.94 | PTGS2 (0.73) | KMT2APTGS1PTGS2ALDH1A1ABCB11 | |
| SCHEMBL5071823 | 0.89 | KMT2A (1.00) | KMT2APTGS1PTGS2ALDH1A1ABCB11 | |
| SCHEMBL28940679 | 0.86 | PTGS2 (0.64) | KMT2APTGS1PTGS2ALDH1A1ABCB11 | |
| SCHEMBL1557809 | 0.85 | PTGS2 (0.62) | KMT2APTGS1PTGS2ALDH1A1ABCB11 | |
| SCHEMBL25409790 | 0.84 | KMT2A (0.81) | KMT2APTGS1PTGS2ALDH1A1ABCB11 | |
| SCHEMBL1557659 | 0.82 | PTGS1 (0.74) | KMT2APTGS1PTGS2ALDH1A1MEN1 | |
| SCHEMBL6508487 | 0.82 | KMT2A (0.79) | KMT2APTGS1PTGS2ALDH1A1ABCB11 | |
| SCHEMBL13743029 | 0.82 | KMT2A (0.79) | KMT2APTGS1PTGS2ALDH1A1ABCB11 | |
| SCHEMBL6509069 | 0.82 | PTGS1 (1.00) | KMT2APTGS1PTGS2ALDH1A1ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070293542-A1 | Selective Cox-2 Inhibitors | IRONWOOD PHARMACEUTICALS, INC. | 2007-12-20 | — | — | US | claimed |
| WO-2005037227-A2 | SELECTIVE COX-2 INHIBITORS | MICROBIA, INC. (US) | 2005-04-28 | — | — | WO | claimed |
| US-20070293542-A1 | Selective Cox-2 Inhibitors | IRONWOOD PHARMACEUTICALS, INC. | 2007-12-20 | — | — | US | disclosed |
| US-20070293542-A1 | Selective Cox-2 Inhibitors | IRONWOOD PHARMACEUTICALS, INC. | 2007-12-20 | — | — | US | disclosed |
| US-20070293542-A1 | Selective Cox-2 Inhibitors | IRONWOOD PHARMACEUTICALS, INC. | 2007-12-20 | — | — | US | disclosed |
| WO-2005037227-A2 | SELECTIVE COX-2 INHIBITORS | MICROBIA, INC. (US) | 2005-04-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070293542-A1 | Selective Cox-2 Inhibitors | PTGS2, FAAH2, PTGES2 | KMT2A 1711/4885PTGS1 7/4885PTGS2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.