Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | GRIN2D | O15399 | 7/20 | 0.42 |
| ▸ | GRIN3B | O60391 | 7/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 7/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 7/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 7/20 | 0.42 |
| ▸ | GRIN2C | Q14957 | 7/20 | 0.42 |
| ▸ | GRIN3A | Q8TCU5 | 7/20 | 0.42 |
| ▸ | GRIA1 | P42261 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | THPO | P40225 | 1/20 | 0.42 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.42 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3669922 | 0.84 | GRIN2D (0.54) | KDM4EALDH1A1HPGDSMN1; SMN2GRIN2D | |
| SCHEMBL29909816 | 0.78 | ALDH1A1 (0.47) | KDM4EALDH1A1HPGDSMN1; SMN2GRIN2D | |
| SCHEMBL5368341 | 0.78 | CA12 (0.53) | KDM4EALDH1A1HPGDSMN1; SMN2GRIN2D | |
| SCHEMBL3668179 | 0.78 | KDM4E (0.47) | KDM4EALDH1A1HPGDSMN1; SMN2GRIN2D | |
| SCHEMBL27474539 | 0.78 | GRIN2D (0.58) | KDM4EALDH1A1HPGDSMN1; SMN2GRIN2D | |
| SCHEMBL8137325 | 0.78 | ALDH1A1 (0.47) | KDM4EALDH1A1HPGDSMN1; SMN2GRIN2D | |
| SCHEMBL13814616 | 0.74 | KDM4E (0.47) | KDM4EALDH1A1HPGDSMN1; SMN2GRIN2D | |
| SCHEMBL30826989 | 0.74 | KDM4E (0.47) | KDM4EALDH1A1HPGDSMN1; SMN2GRIN2D | |
| SCHEMBL7021184 | 0.74 | KDM4E (0.47) | KDM4EALDH1A1HPGDSMN1; SMN2GRIN2D | |
| SCHEMBL1291837 | 0.74 | GRIN2D (0.70) | KDM4EALDH1A1HPGDSMN1; SMN2GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7176314-B2 | IkB kinases (IKK) enzyme inhibitors, a imidazole-5-yl-quinoline derivatives compounds | AMGEN, INC. (US) | 2007-02-13 | — | — | US | disclosed |
| US-20030181472-A1 | Inflammation modulators | TULARIK INC. | 2003-09-25 | — | — | US | disclosed |
| WO-2003048152-A2 | INFLAMMATION MODULATORS | TULARIK INC. (US) | 2003-06-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030181472-A1 | Inflammation modulators | NFATC1, NFKBIA, RELA | KDM4E 3338/4885ALDH1A1 2585/4885HPGD 406/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.