SCHEMBL5546266

SCHEMBL5546266

OCCC1CCN(Nc2ccc(F)c(Cl)c2)CC1

nearest known ligand 0.46

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
EGFR P00533 2/20 0.46
POLB P06746 1/20 0.44
MAPT P10636 5/20 0.42
KMT2A Q03164 3/20 0.42
MEN1 O00255 2/20 0.42
ALDH1A1 P00352 2/20 0.42
TSHR P16473 1/20 0.42
HPGD P15428 1/20 0.41
TP53 P04637 1/20 0.41
LMNA P02545 3/20 0.41
MALT1 Q9UDY8 1/20 0.40
HTT P42858 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
THRB P10828 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5547460 0.89 ALOX5 (0.46) POLBMAPTKMT2AMEN1ALDH1A1
SCHEMBL5550840 0.82 KMT2A (0.47) MAPTKMT2AMEN1ALDH1A1TSHR
SCHEMBL5546241 0.81 USP30 (0.43) POLBMAPTKMT2AMEN1ALDH1A1
SCHEMBL5547427 0.79 MAPT (0.45) EGFRMAPTKMT2AMEN1ALDH1A1
SCHEMBL5550055 0.78 KDM4E (0.43) POLBKMT2AMEN1ALDH1A1SMN1; SMN2
SCHEMBL5550018 0.77 AKR1C3 (0.36) KMT2AMEN1ALDH1A1LMNASMN1; SMN2
SCHEMBL5550036 0.77 KMT2A (0.45) MAPTKMT2AMEN1ALDH1A1TSHR
SCHEMBL5550802 0.77 MAPT (0.56) MAPTKMT2AMEN1ALDH1A1TSHR
SCHEMBL5550024 0.75 MAPT (0.55) MAPTKMT2AMEN1ALDH1A1TSHR
SCHEMBL5550676 0.73 MAPT (0.46) MAPTKMT2AMEN1ALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2002000649-A9 SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS ASTRAZENECA AB (SE) 2007-09-20 WO disclosed
CN-1496364-A Substituted quinazoline derivatives and their use as inhibitors 2004-05-12 CN disclosed
EP-1299381-A1 SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS AstraZeneca AB (SE) 2003-04-09 EP disclosed
WO-2002000649-A1 SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS ASTRAZENECA AB (SE) 2002-01-03 WO disclosed