Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | AHR | P35869 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5550036 | 0.91 | KMT2A (0.45) | KMT2AMEN1ALDH1A1MAPTHTT | |
| SCHEMBL5547460 | 0.84 | ALOX5 (0.46) | KMT2AMEN1ALDH1A1MAPTHTT | |
| SCHEMBL5551976 | 0.83 | MAPT (0.46) | KMT2AMEN1ALDH1A1MAPTHTT | |
| SCHEMBL5550802 | 0.82 | MAPT (0.56) | KMT2AMEN1ALDH1A1MAPTHTT | |
| SCHEMBL5546266 | 0.82 | EGFR (0.46) | KMT2AMEN1ALDH1A1MAPTHTT | |
| SCHEMBL5550024 | 0.81 | MAPT (0.55) | KMT2AMEN1ALDH1A1MAPTHTT | |
| SCHEMBL27262053 | 0.78 | LMNA (0.64) | KMT2AMEN1ALDH1A1MAPTHTT | |
| SCHEMBL5550676 | 0.78 | MAPT (0.46) | KMT2AMEN1ALDH1A1MAPTHTT | |
| SCHEMBL5551989 | 0.78 | KMT2A (0.44) | KMT2AMEN1ALDH1A1MAPTHTT | |
| SCHEMBL5547459 | 0.75 | KDM4E (0.44) | KMT2AMEN1ALDH1A1MAPTTRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002000649-A9 | SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS | ASTRAZENECA AB (SE) | 2007-09-20 | — | — | WO | disclosed |
| CN-1496364-A | Substituted quinazoline derivatives and their use as inhibitors | — | 2004-05-12 | — | — | CN | disclosed |
| EP-1299381-A1 | SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS | AstraZeneca AB (SE) | 2003-04-09 | — | — | EP | disclosed |
| WO-2002000649-A1 | SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS | ASTRAZENECA AB (SE) | 2002-01-03 | — | — | WO | disclosed |