Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5022929 | 0.89 | PPARG (0.44) | LMNAKDM4EKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL5016943 | 0.87 | KDM4E (0.49) | LMNAKDM4EKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL5016981 | 0.84 | LMNA (0.47) | LMNAKDM4EKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL5016960 | 0.82 | MAPT (0.51) | LMNAKDM4EKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL5016994 | 0.79 | LMNA (0.49) | LMNAKDM4EKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL5023488 | 0.79 | KDM4E (0.52) | LMNAKDM4EKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL5023100 | 0.73 | SMN1; SMN2 (0.46) | LMNAKDM4EKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL5023114 | 0.71 | SMN1; SMN2 (0.47) | LMNAKDM4EKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL5016973 | 0.71 | KDM4E (0.50) | LMNAKDM4EKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL5016923 | 0.71 | SMN1; SMN2 (0.57) | LMNAKDM4EMAPTSMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7297707-B2 | Benzothiazolyl derivatives | HOFFMANN-LA ROCHE INC. (US) | 2007-11-20 | — | — | US | claimed |
| US-20040266845-A1 | Benzothiazolyl derivatives | HOFFMANN-LA ROCHE INC. | 2004-12-30 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040266845-A1 | Benzothiazolyl derivatives | CNR1, CNR2, GPR119 | LMNA 4004/4885KDM4E 1919/4885KMT2A 2119/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.