Glutarate

Glutarate

SCHEMBL5546487

CC(N)O.CC(N)O.CC(N)O.CC(N)O.CCCCC(=O)O.O=C(O)CCC(=O)O.O=C(O)CCCC(=O)O

nearest known ligand 0.56

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4

The experimentally established mechanism targets of Glutarate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1B1 P15121 1/20 0.56
GPR84 Q9NQS5 7/20 0.54
PPARG P37231 7/20 0.54
PPARD Q03181 7/20 0.54
PPARA Q07869 7/20 0.54
HDAC11 Q96DB2 5/20 0.54
TSHR P16473 4/20 0.54
PTPN1 P18031 3/20 0.54
ALDH1A1 P00352 3/20 0.54
TLR2 O60603 2/20 0.54
TDP1 Q9NUW8 2/20 0.54
FABP4 P15090 2/20 0.54
FFAR1 O14842 2/20 0.54
FFAR4 Q5NUL3 2/20 0.54
KMT2A Q03164 2/20 0.54
SLC22A6 Q4U2R8 2/20 0.54
SLC22A8 Q8TCC7 1/20 0.54
MEN1 O00255 1/20 0.54
ESR1 P03372 1/20 0.54
ALOX15 P16050 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Succinic Acid SCHEMBL5550345 0.98 AKR1B1 (0.58) AKR1B1GPR84PPARGPPARDPPARA
Valeric Acid SCHEMBL1830437 0.96 AKR1B1 (0.61) AKR1B1GPR84PPARGPPARDPPARA
Hexanoate SCHEMBL1836892 0.89 AKR1B1 (0.73) AKR1B1GPR84PPARGPPARDPPARA
Valeric Acid SCHEMBL21145338 0.89 AKR1B1 (0.64) AKR1B1GPR84PPARGPPARDPPARA
Glutarate SCHEMBL5874258 0.89 SLC22A6 (0.61) AKR1B1GPR84PPARGPPARDPPARA
Stearic Acid SCHEMBL5874483 0.87 GPR84 (0.74) AKR1B1GPR84PPARGPPARDPPARA
Undecanoate SCHEMBL5552202 0.87 GPR84 (0.74) AKR1B1GPR84PPARGPPARDPPARA
Undecanoate SCHEMBL1833641 0.87 GPR84 (0.74) AKR1B1GPR84PPARGPPARDPPARA
Heptanoate SCHEMBL1832308 0.87 GPR84 (0.74) AKR1B1GPR84PPARGPPARDPPARA
Dodecanoate SCHEMBL1833964 0.87 GPR84 (0.74) AKR1B1GPR84PPARGPPARDPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1805131-A2 IONIC LIQUIDS COMPRISING NITROGEN CONTAINING CATIONS THE UNIVERSITY OF YORK (GB) 2007-07-11 EP disclosed
WO-2005097731-A2 IONIC LIQUIDS COMPRISING NITROGEN CONTAINING CATIONS THE UNIVERSITY OF YORK (GB) 2005-10-20 WO disclosed