Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.31 |
| ▸ | IDH2 | P48735 | 1/20 | 0.30 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7131198 | 0.89 | KMT2A (0.37) | RAB9ANPC1SMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL5550725 | 0.84 | KDM4E (0.46) | RAB9ANPC1SMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL5550036 | 0.75 | KMT2A (0.45) | KMT2AALDH1A1LMNAMEN1 | |
| SCHEMBL5550835 | 0.75 | KDM4E (0.44) | RAB9ANPC1SMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL27674819 | 0.75 | LMNA (0.43) | RAB9ANPC1SMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL5547459 | 0.73 | KDM4E (0.44) | RAB9ANPC1SMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL5550018 | 0.72 | AKR1C3 (0.36) | RAB9ANPC1SMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL7125472 | 0.71 | KMT2A (0.39) | RAB9ANPC1SMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL5550674 | 0.71 | MAPT (0.43) | RAB9ANPC1KMT2AALDH1A1LMNA | |
| SCHEMBL3637983 | 0.70 | AR (0.43) | SMN1; SMN2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002000649-A9 | SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS | ASTRAZENECA AB (SE) | 2007-09-20 | — | — | WO | disclosed |
| EP-1299381-A1 | SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS | AstraZeneca AB (SE) | 2003-04-09 | — | — | EP | disclosed |
| WO-2002000649-A1 | SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS | ASTRAZENECA AB (SE) | 2002-01-03 | — | — | WO | disclosed |