Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5550725 | 0.91 | KDM4E (0.46) | KDM4EALDH1A1NPC1KMT2ARAB9A | |
| SCHEMBL5550133 | 0.83 | KDM4E (0.45) | KDM4EALDH1A1NPC1KMT2ARAB9A | |
| SCHEMBL7131198 | 0.83 | KMT2A (0.37) | ALDH1A1NPC1KMT2ARAB9AMEN1 | |
| SCHEMBL5550835 | 0.82 | KDM4E (0.44) | KDM4EALDH1A1NPC1KMT2ARAB9A | |
| SCHEMBL5547476 | 0.81 | ALDH1A1 (0.54) | KDM4EALDH1A1NPC1KMT2ARAB9A | |
| SCHEMBL5550055 | 0.81 | KDM4E (0.43) | KDM4EALDH1A1NPC1KMT2ARAB9A | |
| SCHEMBL5551989 | 0.81 | KMT2A (0.44) | ALDH1A1NPC1KMT2ARAB9AMEN1 | |
| SCHEMBL17287922 | 0.80 | NPC1 (0.62) | KDM4EALDH1A1NPC1KMT2ARAB9A | |
| SCHEMBL5550694 | 0.80 | ALDH1A1 (0.53) | KDM4EALDH1A1NPC1KMT2ARAB9A | |
| SCHEMBL2406119 | 0.77 | KMT2A (0.49) | KDM4EALDH1A1NPC1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002000649-A9 | SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS | ASTRAZENECA AB (SE) | 2007-09-20 | — | — | WO | disclosed |
| CN-1496364-A | Substituted quinazoline derivatives and their use as inhibitors | — | 2004-05-12 | — | — | CN | disclosed |
| EP-1299381-A1 | SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS | AstraZeneca AB (SE) | 2003-04-09 | — | — | EP | disclosed |
| WO-2002000649-A1 | SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS | ASTRAZENECA AB (SE) | 2002-01-03 | — | — | WO | disclosed |