Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 13/20 | 0.54 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.39 |
| ▸ | XIAP | P98170 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5553170 | 0.95 | MTNR1A (0.58) | MTNR1AMTNR1BTRPV1 | |
| SCHEMBL1981078 | 0.93 | MTNR1A (0.54) | MTNR1AMTNR1BTRPV1XIAP | |
| SCHEMBL27742049 | 0.89 | MTNR1A (0.52) | MTNR1AMTNR1BTRPV1XIAP | |
| SCHEMBL1981918 | 0.88 | MTNR1A (0.57) | MTNR1AMTNR1BTRPV1 | |
| SCHEMBL27742046 | 0.87 | MTNR1A (0.54) | MTNR1AMTNR1BTRPV1XIAP | |
| SCHEMBL5548647 | 0.85 | MTNR1A (0.41) | MTNR1AMTNR1BTRPV1 | |
| SCHEMBL27762610 | 0.84 | MTNR1A (0.56) | MTNR1AMTNR1BTRPV1 | |
| SCHEMBL16495004 | 0.83 | MTNR1A (0.47) | MTNR1AMTNR1BTRPV1 | |
| SCHEMBL1981077 | 0.83 | TRPV1 (0.56) | MTNR1ATRPV1 | |
| SCHEMBL1981234 | 0.83 | MTNR1A (0.56) | MTNR1AMTNR1BTRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844038-A2 | CHROMANYLUREA COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR AND USES THEREOF | ABBOTT LABORATORIES (US) | 2007-10-17 | — | — | EP | claimed |
| WO-2006065484-A2 | CHROMANYLUREA COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR AND USES THEREOF | ABBOTT LABORATORIES (US) | 2006-06-22 | — | — | WO | claimed |