Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 11/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.37 |
| ▸ | CCKBR | P32239 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1979504 | 0.92 | MTNR1A (0.41) | MTNR1AMTNR1BTRPV1 | |
| SCHEMBL27742034 | 0.89 | CCKBR (0.42) | MTNR1AMTNR1BEPHX1TRPV1CCKBR | |
| SCHEMBL5553170 | 0.86 | MTNR1A (0.58) | MTNR1AMTNR1BTRPV1CCKBR | |
| SCHEMBL27742030 | 0.86 | MTNR1A (0.41) | MTNR1AMTNR1BTRPV1CCKBR | |
| SCHEMBL5547623 | 0.85 | MTNR1A (0.54) | MTNR1AMTNR1BTRPV1 | |
| SCHEMBL1980371 | 0.82 | TRPV1 (0.51) | TRPV1 | |
| SCHEMBL16495004 | 0.81 | MTNR1A (0.47) | MTNR1AMTNR1BTRPV1 | |
| Acetic Acid SCHEMBL27742031 | 0.81 | TRPV1 (0.49) | MTNR1ATRPV1 | |
| SCHEMBL1981234 | 0.81 | MTNR1A (0.56) | MTNR1AMTNR1BTRPV1 | |
| SCHEMBL27818704 | 0.80 | MTNR1A (0.44) | MTNR1AMTNR1BTRPV1CCKBR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844038-A2 | CHROMANYLUREA COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR AND USES THEREOF | ABBOTT LABORATORIES (US) | 2007-10-17 | — | — | EP | claimed |
| WO-2006065484-A2 | CHROMANYLUREA COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR AND USES THEREOF | ABBOTT LABORATORIES (US) | 2006-06-22 | — | — | WO | claimed |