Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 10/20 | 0.65 |
| ▸ | CACNA1B | Q00975 | 10/20 | 0.65 |
| ▸ | CACNB1 | Q02641 | 10/20 | 0.65 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.43 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.41 |
| ▸ | TACR2 | P21452 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6499599 | 0.87 | CACNA2D1 (0.50) | CACNA2D1CACNA1BCACNB1CACNA1CMEN1 | |
| SCHEMBL13701483 | 0.81 | CACNA2D1 (0.73) | CACNA2D1CACNA1BCACNB1CACNA1CMEN1 | |
| SCHEMBL4841732 | 0.79 | ACHE (0.55) | CACNA2D1CACNA1BCACNB1CACNA1CMEN1 | |
| SCHEMBL3861078 | 0.79 | CACNA2D1 (1.00) | CACNA2D1CACNA1BCACNB1CACNA1CALDH1A1 | |
| Hydrochloric Acid SCHEMBL6372221 | 0.79 | ACHE (0.54) | CACNA2D1CACNA1BCACNB1CACNA1CMEN1 | |
| SCHEMBL5548264 | 0.78 | CACNA2D1 (0.55) | CACNA2D1CACNA1BCACNB1CACNA1CALDH1A1 | |
| SCHEMBL4275876 | 0.76 | CACNA2D1 (0.73) | CACNA2D1CACNA1BCACNB1CACNA1CCHRM1 | |
| SCHEMBL4286091 | 0.75 | CACNA2D1 (0.71) | CACNA2D1CACNA1BCACNB1CACNA1CMEN1 | |
| SCHEMBL4284711 | 0.75 | CACNA2D1 (0.71) | CACNA2D1CACNA1BCACNB1CACNA1CMEN1 | |
| SCHEMBL8212834 | 0.74 | CACNA2D1 (0.91) | CACNA2D1CACNA1BCACNB1CACNA1CLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1745042-A1 | DIARYLAMINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | Neuromed Pharmaceuticals, Ltd. (CA) | 2007-01-24 | — | — | EP | claimed |
| WO-2005097779-A1 | DIARYLAMINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | NEUROMED PHARMACEUTICALS LTD. (CA) | 2005-10-20 | — | — | WO | claimed |