Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 8/20 | 0.55 |
| ▸ | CACNA1B | Q00975 | 8/20 | 0.55 |
| ▸ | CACNB1 | Q02641 | 8/20 | 0.55 |
| ▸ | CACNA1C | Q13936 | 8/20 | 0.55 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.52 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.52 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5547625 | 0.88 | CACNA2D1 (0.52) | CACNA2D1CACNA1BCACNB1CACNA1CCHRM4 | |
| SCHEMBL7339023 | 0.86 | CACNA2D1 (0.65) | CACNA2D1CACNA1BCACNB1CACNA1CCHRM4 | |
| SCHEMBL7339537 | 0.79 | CACNA2D1 (0.56) | CACNA2D1CACNA1BCACNB1CACNA1CCHRM4 | |
| SCHEMBL17285967 | 0.78 | ALDH1A1 (0.46) | CACNA2D1CACNA1BCACNB1CACNA1CALDH1A1 | |
| SCHEMBL5547696 | 0.78 | CACNA2D1 (0.65) | CACNA2D1CACNA1BCACNB1CACNA1CCHRM4 | |
| SCHEMBL7346358 | 0.78 | ALDH1A1 (0.62) | CACNA2D1CACNA1BCACNB1CACNA1CALDH1A1 | |
| SCHEMBL7340551 | 0.77 | CACNA2D1 (0.56) | CACNA2D1CACNA1BCACNB1CACNA1CALDH1A1 | |
| SCHEMBL7342475 | 0.77 | CACNA2D1 (0.54) | CACNA2D1CACNA1BCACNB1CACNA1CALDH1A1 | |
| SCHEMBL7342508 | 0.77 | CACNA2D1 (0.54) | CACNA2D1CACNA1BCACNB1CACNA1CALDH1A1 | |
| SCHEMBL7375673 | 0.76 | CACNA2D1 (0.48) | CACNA2D1CACNA1BCACNB1CACNA1CCHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1745042-A1 | DIARYLAMINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | Neuromed Pharmaceuticals, Ltd. (CA) | 2007-01-24 | — | — | EP | claimed |
| WO-2005097779-A1 | DIARYLAMINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | NEUROMED PHARMACEUTICALS LTD. (CA) | 2005-10-20 | — | — | WO | claimed |
| US-20050227999-A1 | Diarylamine derivatives as calcium channel blockers | NEUROMED TECHNOLOGIES INC. | 2005-10-13 | — | — | US | claimed |
| US-20050227999-A1 | Diarylamine derivatives as calcium channel blockers | NEUROMED TECHNOLOGIES INC. | 2005-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050227999-A1 | Diarylamine derivatives as calcium channel blockers | ORAI1, CACNA1D, CACNA1C | CACNA2D1 51/4885CACNA1B 4/4885CACNB1 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.