Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | HPGDS | O60760 | 10/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | MGAM | O43451 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28351499 | 0.88 | ALOX15 (0.48) | ALOX15HTTPSMD14MAPK1HPGDS | |
| SCHEMBL29505143 | 0.78 | ALOX15 (0.65) | ALOX15HTTPSMD14HPGDSKDM4E | |
| SCHEMBL2031896 | 0.78 | ALOX15 (0.65) | ALOX15HTTPSMD14HPGDSKDM4E | |
| SCHEMBL10466162 | 0.76 | HTT (0.67) | ALOX15HTTPSMD14MAPK1HPGDS | |
| SCHEMBL28946126 | 0.76 | ALOX15 (0.54) | ALOX15HTTPSMD14MAPK1HPGDS | |
| SCHEMBL1043657 | 0.76 | HPGDS (0.52) | ALOX15HTTPSMD14MAPK1HPGDS | |
| SCHEMBL17221411 | 0.76 | MAOB (0.53) | ALOX15HTTPSMD14MAPK1HPGDS | |
| SCHEMBL2899731 | 0.75 | PTPN11 (0.53) | ALOX15HTTKDM4EATMALDH1A1 | |
| SCHEMBL8890461 | 0.75 | LCK (0.50) | ALOX15HTTKDM4EATMALDH1A1 | |
| SCHEMBL2001821 | 0.75 | HPGDS (0.51) | ALOX15HTTPSMD14MAPK1HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1780211-A2 | Vanilloid receptor ligands and their use in treatments | Amgen Inc. (US) | 2007-05-02 | — | — | EP | disclosed |
| EP-1775295-A1 | Vanilloid receptor ligands and their use in treatments | Amgen Inc. (US) | 2007-04-18 | — | — | EP | disclosed |