Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 1/20 | 0.56 |
| ▸ | NAMPT | P43490 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 5/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | ALPL | P05186 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5548725 | 0.99 | CSNK1D (0.54) | CSNK1DNAMPTEPHX2NPC1TDP1 | |
| SCHEMBL5547801 | 0.82 | MEN1 (0.53) | EPHX2KMT2AMEN1HPGDTSHR | |
| SCHEMBL5547776 | 0.80 | RXFP1 (0.45) | CSNK1DEPHX2KMT2AMEN1 | |
| SCHEMBL5551875 | 0.77 | MEN1 (0.50) | KMT2AMEN1TSHRKDM4E | |
| SCHEMBL5551417 | 0.77 | TDP1 (0.52) | TDP1KMT2AMEN1POLB | |
| SCHEMBL13568424 | 0.75 | EPHX2 (0.59) | CSNK1DNAMPTEPHX2NPC1TDP1 | |
| SCHEMBL5551918 | 0.75 | TP53 (0.40) | CSNK1DKMT2ASMN1; SMN2MEN1CYP2D6 | |
| SCHEMBL16254222 | 0.74 | USP30 (0.64) | CSNK1DNAMPTEPHX2NPC1RAB9A | |
| SCHEMBL5782488 | 0.73 | DYRK1A (0.47) | KMT2ASMN1; SMN2MEN1CYP1A2CYP3A4 | |
| SCHEMBL11973806 | 0.73 | MEN1 (0.42) | EPHX2RAB9AKMT2AMEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1780211-A2 | Vanilloid receptor ligands and their use in treatments | Amgen Inc. (US) | 2007-05-02 | — | — | EP | disclosed |
| EP-1775295-A1 | Vanilloid receptor ligands and their use in treatments | Amgen Inc. (US) | 2007-04-18 | — | — | EP | disclosed |