Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 5/20 | 0.49 |
| ▸ | ENPP3 | O14638 | 4/20 | 0.45 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.45 |
| ▸ | ENPP1 | P22413 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5551875 | 0.93 | MEN1 (0.50) | MEN1TSHRKMT2ARXFP1ALDH1A1 | |
| SCHEMBL5552001 | 0.88 | MEN1 (0.46) | MEN1TSHRKMT2ARXFP1ALDH1A1 | |
| SCHEMBL5551386 | 0.85 | KDM4E (0.47) | MEN1TSHRKMT2AALDH1A1EPHX2 | |
| SCHEMBL5547807 | 0.83 | EPHX2 (0.48) | MEN1TSHRKMT2AALDH1A1EPHX2 | |
| SCHEMBL5548685 | 0.82 | ABL1 (0.48) | MEN1KMT2AALDH1A1PTPN1 | |
| SCHEMBL5547738 | 0.82 | CSNK1D (0.56) | MEN1TSHRKMT2AHPGDEPHX2 | |
| SCHEMBL5548725 | 0.80 | CSNK1D (0.54) | MEN1TSHRKMT2AHPGDEPHX2 | |
| SCHEMBL3282828 | 0.80 | SMN1; SMN2 (0.43) | MEN1TSHRKMT2A | |
| SCHEMBL3282830 | 0.80 | SMN1; SMN2 (0.43) | MEN1TSHRKMT2A | |
| SCHEMBL3282834 | 0.80 | SMN1; SMN2 (0.43) | MEN1TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1780211-A2 | Vanilloid receptor ligands and their use in treatments | Amgen Inc. (US) | 2007-05-02 | — | — | EP | disclosed |
| EP-1775295-A1 | Vanilloid receptor ligands and their use in treatments | Amgen Inc. (US) | 2007-04-18 | — | — | EP | disclosed |