Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | LIPC | P11150 | 1/20 | 0.43 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.38 |
| ▸ | MLYCD | O95822 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5547655 | 0.84 | PTPN11 (0.39) | RXFP1LIPCLIPG | |
| SCHEMBL5547738 | 0.80 | CSNK1D (0.56) | CSNK1DEPHX2MEN1KMT2A | |
| SCHEMBL5547926 | 0.79 | DRD2 (0.50) | LIPCLIPG | |
| SCHEMBL16319711 | 0.79 | NPC1 (0.41) | OPRK1GAAEPHX2MEN1KMT2A | |
| SCHEMBL5548725 | 0.78 | CSNK1D (0.54) | CSNK1DEPHX2MEN1KMT2A | |
| SCHEMBL16319993 | 0.75 | TSHR (0.43) | MEN1KMT2AGRM4 | |
| SCHEMBL5547801 | 0.73 | MEN1 (0.53) | RXFP1EPHX2MEN1KMT2A | |
| SCHEMBL16319407 | 0.73 | OPRM1 (0.42) | HDAC6HDAC3HDAC4HDAC1MLYCD | |
| SCHEMBL1241128 | 0.73 | RXFP1 (0.61) | RXFP1LIPCLIPGPIM1GAA | |
| SCHEMBL30288262 | 0.73 | RXFP1 (0.61) | RXFP1LIPCLIPGPIM1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1780211-A2 | Vanilloid receptor ligands and their use in treatments | Amgen Inc. (US) | 2007-05-02 | — | — | EP | disclosed |
| EP-1775295-A1 | Vanilloid receptor ligands and their use in treatments | Amgen Inc. (US) | 2007-04-18 | — | — | EP | disclosed |