Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.66 |
| ▸ | TSHR | P16473 | 2/20 | 0.66 |
| ▸ | NPC1 | O15118 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 1/20 | 0.65 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.65 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 4/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | HTT | P42858 | 2/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | USP2 | O75604 | 3/20 | 0.62 |
| ▸ | TP53 | P04637 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6705746 | 0.80 | ALDH1A1 (1.00) | ALDH1A1TSHRGRIA3GRIA4MAPT | |
| SCHEMBL6705768 | 0.79 | ALDH1A1 (0.78) | ALDH1A1TSHRNPC1RAB9AGRIA3 | |
| SCHEMBL28669990 | 0.79 | ALDH1A1 (0.76) | ALDH1A1TSHRGRIA3GRIA4MAPT | |
| SCHEMBL6705709 | 0.79 | GRIA3 (1.00) | ALDH1A1TSHRGRIA3GRIA4MAPT | |
| SCHEMBL6705972 | 0.79 | ALDH1A1 (1.00) | ALDH1A1TSHRGRIA3GRIA4MAPT | |
| SCHEMBL6705731 | 0.77 | ALDH1A1 (0.77) | ALDH1A1TSHRGRIA3GRIA4MAPT | |
| SCHEMBL28664531 | 0.77 | ALDH1A1 (0.78) | ALDH1A1TSHRNPC1RAB9AGRIA3 | |
| SCHEMBL6706698 | 0.77 | ALDH1A1 (0.79) | ALDH1A1TSHRGRIA3GRIA4MAPT | |
| SCHEMBL31072433 | 0.76 | ALDH1A1 (0.82) | ALDH1A1TSHRGRIA3GRIA4MAPT | |
| SCHEMBL31072432 | 0.76 | ALDH1A1 (0.82) | ALDH1A1TSHRGRIA3GRIA4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120122910-A1 | METHOD OF TREATING CANCER USING A SURVIVIN INHIBITOR | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2012-05-17 | — | — | US | disclosed |
| US-20120122910-A1 | METHOD OF TREATING CANCER USING A SURVIVIN INHIBITOR | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2012-05-17 | — | — | US | disclosed |
| WO-2010083505-A1 | METHOD OF TREATING CANCER USING A SURVIVIN INHIBITOR | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2010-07-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122910-A1 | METHOD OF TREATING CANCER USING A SURVIVIN INHIBITOR | BIRC5, CDC20, CCNB1 | ALDH1A1 1765/4885TSHR 4503/4885NPC1 2998/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.