Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 2/20 | 0.53 |
| ▸ | GSK3A | P49840 | 4/20 | 0.50 |
| ▸ | GSK3B | P49841 | 4/20 | 0.50 |
| ▸ | PDE5A | O76074 | 3/20 | 0.42 |
| ▸ | PDE1A | P54750 | 1/20 | 0.42 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | INSR | P06213 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | GBA1 | P04062 | 2/20 | 0.42 |
| ▸ | F2 | P00734 | 2/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5548920 | 0.88 | ADORA1 (0.50) | ADORA1GSK3AGSK3BPDE5AINSR | |
| SCHEMBL3525903 | 0.88 | ADORA1 (0.50) | ADORA1GSK3AGSK3BPDE5AINSR | |
| SCHEMBL5548924 | 0.79 | ADORA1 (0.54) | ADORA1GSK3AGSK3BPDE5AGBA1 | |
| SCHEMBL5550083 | 0.78 | ADORA1 (0.53) | ADORA1GSK3AGSK3BPDE5AGBA1 | |
| SCHEMBL5543633 | 0.77 | ADORA1 (0.50) | ADORA1GSK3AGSK3BPDE5AINSR | |
| SCHEMBL3527078 | 0.77 | ADORA1 (0.46) | ADORA1GSK3AGSK3BPDE5AINSR | |
| SCHEMBL5549306 | 0.77 | ADORA1 (0.52) | ADORA1GSK3AGSK3BPDE5AGBA1 | |
| SCHEMBL5548882 | 0.77 | ADORA1 (0.45) | ADORA1GSK3AGSK3BPDE5AINSR | |
| SCHEMBL5550010 | 0.77 | ADORA1 (0.45) | ADORA1GSK3AGSK3BINSRIGF1R | |
| SCHEMBL5549322 | 0.77 | ADORA1 (0.45) | ADORA1GSK3AGSK3BPDE5AINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678180-B1 | SUBSTITUTED 2H-[1,2,4]TRIAZOLO 4,3-A PYRAZINES AS GSK-3 INHIBITORS | PFIZER PROD INC (US) | 2007-08-08 | — | — | EP | disclosed |