SCHEMBL5548512

SCHEMBL5548512

CC[Si](CC)(C1C(C)=Cc2c(-c3ccc(C(C)(C)C)cc3)cccc21)C1C(C)=Cc2c(-c3ccc(C(C)(C)C)cc3)cccc21

nearest known ligand 0.32

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 1/20 0.32
CREBBP Q92793 1/20 0.32
SMN1; SMN2 Q16637 2/20 0.32
KDM4E B2RXH2 1/20 0.32
ALDH1A1 P00352 1/20 0.32
HPGD P15428 1/20 0.32
HTT P42858 1/20 0.32
HSD17B10 Q99714 1/20 0.32
NPC1 O15118 1/20 0.31
LMNA P02545 1/20 0.31
TP53 P04637 1/20 0.31
RAB9A P51151 1/20 0.31
KIF11 P52732 2/20 0.31
S1PR1 P21453 1/20 0.31
DGAT1 O75907 1/20 0.31
OPRD1 P41143 1/20 0.30
NR1H4 Q96RI1 3/20 0.30
PTAFR P25105 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3425601 0.93 SMN1; SMN2 (0.30) SMN1; SMN2KDM4EALDH1A1HPGDHTT
SCHEMBL5548676 0.90 CDK4 (0.31) BRD4CREBBPSMN1; SMN2KDM4EALDH1A1
SCHEMBL31043490 0.88
SCHEMBL5607347 0.88 CNR1 (0.33)
SCHEMBL3402757 0.88 NR1H4 (0.31) BRD4CREBBPSMN1; SMN2KDM4EALDH1A1
SCHEMBL5607920 0.87 CNR1 (0.34)
SCHEMBL4874583 0.86 CNR2 (0.36) SMN1; SMN2ALDH1A1
SCHEMBL1455223 0.85 NPC1 (0.36) BRD4CREBBPSMN1; SMN2KDM4EALDH1A1
SCHEMBL3397237 0.84
SCHEMBL5549218 0.84 BRD4 (0.30) BRD4CREBBP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3925988-B1 HYBRIDE SUPPORTED METALLOCENE CATALYST AND METHOD FOR PREPARING POLYPROPYLENE USING THE SAME LG CHEMICAL LTD (KR) 2023-10-04 EP disclosed
EP-2915824-B1 METALLOCENE LIGANDS, METALLOCENE COMPOUNDS AND METALLOCENE CATALYSTS, THEIR SYNTHESIS AND THEIR USE FOR THE POLYMERIZATION OF OLEFINS LUMMUS NOVOLEN TECHNOLOGY GMBH (DE) 2022-05-25 EP disclosed
US-20220056163-A1 Hybrid Supported Metallocene Catalyst and Method for Preparing Polypropylene Using the Same LG CHEM, LTD. (KR) 2022-02-24 US disclosed
EP-3925988-A1 HYBRID SUPPORTED METALLOCENE CATALYST AND METHOD FOR PREPARING POLYPROPYLENE USING SAME LG CHEM, LTD. (KR) 2021-12-22 EP disclosed
WO-2021034170-A1 HYBRID SUPPORTED METALLOCENE CATALYST AND METHOD FOR PREPARING POLYPROPYLENE USING SAME 주식회사 엘지화학 2021-02-25 WO disclosed
EP-2915824-A1 METALLOCENE LIGANDS, METALLOCENE COMPOUNDS AND METALLOCENE CATALYSTS, THEIR SYNTHESIS AND THEIR USE FOR THE POLYMERIZATION OF OLEFINS Lummus Novolen Technology Gmbh (DE) 2015-09-09 EP disclosed
EP-1828266-B1 SUPPORTED METALLOCENE CATALYST COMPOSITIONS, THEIR SYNTHESIS AND THEIR USE FOR THE POLYMERIZATION OF OLEFINS LUMMUS NOVOLEN TECHNOLOGY GMBH (DE) 2015-07-22 EP disclosed
US-7285608-B2 Metallocene ligands, metallocene compounds and metallocene catalysts, their synthesis and their use for the polymerization of olefins NOVOLEN TECHNOLOGY HOLDINGS C.V. (NL) 2007-10-23 US disclosed
EP-1828266-A1 METALLOCENE CATALYSTS, THEIR SYNTHESIS AND THEIR USE FOR THE POLYMERIZATION OF OLEFINS Novolen Technology Holdings, C.V. (NL) 2007-09-05 EP disclosed
WO-2006060544-A1 METALLOCENE CATALYSTS, THEIR SYNTHESIS AND THEIR USE FOR THE POLYMERIZATION OF OLEFINS NOVOLEN TECHNOLOGY HOLDINGS C.V. (NL) 2006-06-08 WO disclosed
US-20050239979-A1 Metallocene ligands, metallocene compounds and metallocene catalysts, their synthesis and their use for the polymerization of olefins LUMMUS NOVOLEN TECHNOLOGY GMBH (DE) 2005-10-27 US disclosed