Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.43 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.43 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5550115 | 0.88 | GAA (0.45) | GAAPOLBKDM4EALDH1A1HSD17B10 | |
| SCHEMBL5548577 | 0.88 | GAA (0.45) | GAAPOLBKDM4EALDH1A1HSD17B10 | |
| SCHEMBL5543566 | 0.76 | MAPK1 (0.52) | GAAPOLBKDM4EALDH1A1HSD17B10 | |
| SCHEMBL5545608 | 0.76 | MAPK1 (0.51) | GAAPOLBKDM4EALDH1A1HSD17B10 | |
| SCHEMBL3526664 | 0.75 | GAA (0.45) | GAAPOLBKDM4EALDH1A1HSD17B10 | |
| SCHEMBL5549356 | 0.75 | ALDH1A1 (0.55) | GAAPOLBKDM4EALDH1A1HSD17B10 | |
| SCHEMBL10518348 | 0.68 | KDM4E (0.46) | GAAPOLBKDM4EALDH1A1HSD17B10 | |
| SCHEMBL5549410 | 0.68 | TLR9 (0.43) | GAAPOLBKDM4EALDH1A1HSD17B10 | |
| SCHEMBL7238360 | 0.66 | KDM4E (0.62) | GAAPOLBKDM4EALDH1A1HSD17B10 | |
| SCHEMBL10488969 | 0.65 | SMN1; SMN2 (0.50) | GAAPOLBKDM4EALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678180-B1 | SUBSTITUTED 2H-[1,2,4]TRIAZOLO 4,3-A PYRAZINES AS GSK-3 INHIBITORS | PFIZER PROD INC (US) | 2007-08-08 | — | — | EP | disclosed |