Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | ACP1 | P24666 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | TLR9 | Q9NR96 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5545608 | 0.85 | MAPK1 (0.51) | MAPK1TP53ALOX15TSHRACP1 | |
| SCHEMBL5548577 | 0.84 | GAA (0.45) | MAPK1TP53ALOX15TSHRACP1 | |
| SCHEMBL5549356 | 0.77 | ALDH1A1 (0.55) | MAPK1TP53ALOX15TSHRACP1 | |
| SCHEMBL5548536 | 0.76 | GAA (0.47) | MAPK1TP53ALOX15TSHRACP1 | |
| SCHEMBL5548924 | 0.75 | ADORA1 (0.54) | MAPK1TSHRPOLBALDH1A1MAPT | |
| SCHEMBL5550115 | 0.73 | GAA (0.45) | MAPK1TP53ALOX15TSHRACP1 | |
| SCHEMBL3526664 | 0.69 | GAA (0.45) | MAPK1TP53ALOX15TSHRKDM4E | |
| SCHEMBL7238360 | 0.66 | KDM4E (0.62) | MAPK1TP53ALOX15TSHRACP1 | |
| SCHEMBL6135962 | 0.66 | ACP1 (0.43) | MAPK1TP53ALOX15TSHRACP1 | |
| SCHEMBL10367734 | 0.65 | KDM4E (0.57) | MAPK1TP53ALOX15TSHRACP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678180-B1 | SUBSTITUTED 2H-[1,2,4]TRIAZOLO 4,3-A PYRAZINES AS GSK-3 INHIBITORS | PFIZER PROD INC (US) | 2007-08-08 | — | — | EP | disclosed |