Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | CASP3 | P42574 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.34 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.34 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.34 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.33 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5552943 | 0.88 | KDM4E (0.47) | KDM4EMAPTRAB9ASMN1; SMN2KMT2A | |
| SCHEMBL5552339 | 0.85 | AGPAT2 (0.42) | KDM4EMAPTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL14960175 | 0.77 | CASP3 (0.41) | NOTUMKDM4EMAPTCASP3RAB9A | |
| SCHEMBL19936600 | 0.76 | CASP3 (0.40) | NOTUMKDM4EMAPTCASP3RAB9A | |
| SCHEMBL3436648 | 0.75 | KDM4E (0.65) | KDM4EMAPTCASP3RAB9ASMN1; SMN2 | |
| SCHEMBL3436690 | 0.73 | KDM4E (0.42) | NOTUMKDM4EMAPTCASP3RAB9A | |
| SCHEMBL14800709 | 0.71 | GAA (0.68) | KDM4EMAPTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL28288912 | 0.68 | MEN1 (0.44) | NOTUMKDM4EMAPTCASP3RAB9A | |
| SCHEMBL3183519 | 0.68 | MIF (0.48) | NOTUMKDM4EMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL14960117 | 0.67 | ADORA2A (0.39) | NOTUMKDM4EMAPTCASP3RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105753858-B | Heterocyclic compound and p27Kip1Decomposing inhibitor | ASKA制药株式会社 | 2019-04-30 | — | — | CN | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |