Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 2/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.34 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.34 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19936434 | 0.84 | MAPT (0.37) | APPSMN1; SMN2RAB9AMAPTNPC1 | |
| SCHEMBL14960175 | 0.83 | CASP3 (0.41) | CASP3NOTUMSMN1; SMN2RAB9AMAPT | |
| SCHEMBL19936424 | 0.82 | HSP90AA1 (0.46) | MAPTNPC1POLBCRHR1KDM4E | |
| SCHEMBL19936382 | 0.81 | HDAC9 (0.39) | APPMAPT | |
| SCHEMBL2069606 | 0.77 | SMN1; SMN2 (0.56) | CASP3APPSMN1; SMN2RAB9AMAPT | |
| SCHEMBL3436690 | 0.76 | KDM4E (0.42) | CASP3NOTUMSMN1; SMN2RAB9AMAPT | |
| SCHEMBL19936529 | 0.76 | HSD11B1 (0.40) | APPSMN1; SMN2RAB9AMAPTNPC1 | |
| SCHEMBL5548627 | 0.76 | NOTUM (0.38) | CASP3NOTUMSMN1; SMN2RAB9AMAPT | |
| SCHEMBL3436648 | 0.75 | KDM4E (0.65) | CASP3SMN1; SMN2RAB9AMAPTNPC1 | |
| SCHEMBL14800709 | 0.74 | GAA (0.68) | SMN1; SMN2RAB9AMAPTNPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2594555-B1 | HETEROCYCLIC COMPOUND, AND p27 KIP1 DEGRADATION INHIBITOR | ASKA PHARM CO LTD (JP) | 2018-03-07 | — | — | EP | disclosed |