Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 9/20 | 0.46 |
| ▸ | LIPE | Q05469 | 1/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | POLQ | O75417 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5549681 | 0.73 | CFTR (0.46) | CFTRLMNA | |
| SCHEMBL5113785 | 0.70 | DGAT2 (0.53) | CFTR | |
| SCHEMBL5106949 | 0.70 | DGAT2 (0.53) | CFTR | |
| SCHEMBL5549687 | 0.69 | LMNA (0.50) | CFTRLMNA | |
| SCHEMBL9886104 | 0.69 | LMNA (0.43) | CFTRMRGPRX4LMNA | |
| SCHEMBL18930910 | 0.68 | RNF4 (0.60) | NR1H4HTTLMNA | |
| SCHEMBL16395538 | 0.68 | LMNA (0.42) | CFTRHTTMRGPRX4LMNA | |
| SCHEMBL31435386 | 0.68 | LMNA (0.42) | CFTRHTTMRGPRX4LMNA | |
| SCHEMBL6957247 | 0.68 | HTT (0.47) | NR1H4HTTHDAC1HDAC8HDAC6 | |
| SCHEMBL1922639 | 0.68 | PTGDR2 (0.74) | PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807076-A1 | N-(PYRIDIN-3-YL)-2-PHENYLBUTANAMIDES AS ANDROGEN RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2007-07-18 | — | — | EP | claimed |
| WO-2006060108-A1 | N-(PYRIDIN-3-YL)-2-PHENYLBUTANAMIDES AS ANDROGEN RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2006-06-08 | — | — | WO | claimed |
| EP-1807076-A1 | N-(PYRIDIN-3-YL)-2-PHENYLBUTANAMIDES AS ANDROGEN RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006060108-A1 | N-(PYRIDIN-3-YL)-2-PHENYLBUTANAMIDES AS ANDROGEN RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2006-06-08 | — | — | WO | disclosed |