Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GPR183 | P32249 | 1/20 | 0.40 |
| ▸ | ME2 | P23368 | 1/20 | 0.40 |
| ▸ | ME1 | P48163 | 1/20 | 0.40 |
| ▸ | ME3 | Q16798 | 1/20 | 0.40 |
| ▸ | PANK3 | Q9H999 | 3/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5586271 | 0.82 | SCD (0.46) | KMT2AKDM4EALDH1A1HPGDME2 | |
| SCHEMBL3669356 | 0.76 | NPC1 (0.51) | MEN1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL3676046 | 0.70 | SCD (0.54) | MEN1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL9320601 | 0.69 | MEN1 (0.68) | ATMMEN1KMT2AGFERKDM4E | |
| SCHEMBL9410731 | 0.68 | GPR183 (0.56) | ATMMEN1KMT2AGFERALDH1A1 | |
| SCHEMBL11077598 | 0.68 | ATM (0.51) | ATMMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL10911138 | 0.67 | POLB (0.68) | ATMMEN1KMT2AALDH1A1 | |
| SCHEMBL11081503 | 0.67 | KDM4E (0.62) | KDM4EALDH1A1HPGDHSD17B10GPR183 | |
| SCHEMBL24095043 | 0.66 | ADRB2 (0.73) | MEN1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL24095122 | 0.66 | ADRB2 (0.76) | ATMMEN1KMT2AALDH1A1ME2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1763350-A1 | NICOTINAMIDE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2007-03-21 | — | — | EP | disclosed |
| WO-2006014168-A1 | NICOTINAMIDE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2006-02-09 | — | — | WO | disclosed |