Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGM | P11217 | 13/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | TNKS | O95271 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6371759 | 0.83 | PYGM (1.00) | PYGMKDM4ESMN1; SMN2TP53MAPT | |
| SCHEMBL5549678 | 0.80 | PYGM (0.71) | PYGMKDM4ESMN1; SMN2TP53MAPT | |
| SCHEMBL5545532 | 0.79 | PYGM (1.00) | PYGMKDM4ESMN1; SMN2TP53MAPT | |
| SCHEMBL5545726 | 0.77 | PYGM (0.72) | PYGMMAPT | |
| SCHEMBL6371489 | 0.76 | PYGM (1.00) | PYGMKDM4ESMN1; SMN2TP53MAPT | |
| SCHEMBL5550427 | 0.74 | PYGM (0.62) | PYGMKDM4ESMN1; SMN2TP53MAPT | |
| SCHEMBL5549650 | 0.73 | PYGM (0.66) | PYGMKDM4ESMN1; SMN2TP53MAPT | |
| SCHEMBL5549648 | 0.73 | PYGM (0.64) | PYGMKDM4ESMN1; SMN2TP53MAPT | |
| SCHEMBL11250840 | 0.73 | ALDH1A1 (0.47) | KDM4ESMN1; SMN2TP53MAPTMEN1 | |
| SCHEMBL6372041 | 0.73 | PYGM (1.00) | PYGMKDM4ESMN1; SMN2TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711184-B1 | (3-OXO-3,4-DIHYDRO-QUINOXALIN-2-YL-AMINO)-BENZAMIDE DERIVATIVES AND RELATED COMPOUNDS AS GLYCOGEN PHOSPHORYLASE INHIBITORS FOR THE TREATMENT OF DIABETES AND OBESITY | JANSSEN PHARMACEUTICA NV (BE) | 2007-07-18 | — | — | EP | claimed |