Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 5/20 | 0.45 |
| ▸ | PLA2G10 | O15496 | 4/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.39 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.39 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | BCL2 | P10415 | 1/20 | 0.37 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28180065 | 0.83 | PTPN1 (0.46) | PLA2G2APLA2G10ALOX5PTPN1PTPN2 | |
| SCHEMBL11901445 | 0.83 | PLA2G2A (0.46) | PLA2G2APLA2G10ALOX5PTPN1PTPN2 | |
| SCHEMBL28180892 | 0.81 | PLA2G2A (0.45) | PLA2G2APLA2G10PTPN1PTPN2PTPN6 | |
| SCHEMBL28256484 | 0.81 | PLA2G2A (0.47) | PLA2G2APLA2G10PTPN1PTPN2PTPN6 | |
| SCHEMBL28681774 | 0.79 | PLA2G2A (0.57) | PLA2G2APLA2G10SLCO1B1CDC7TSHR | |
| SCHEMBL28193149 | 0.79 | PLA2G2A (0.49) | PLA2G2APLA2G10PTPN1PTPN2PTPN6 | |
| SCHEMBL28180889 | 0.77 | ALDH1A1 (0.41) | PLA2G2APLA2G10PTPN1PTPN2PTPN6 | |
| SCHEMBL5802389 | 0.76 | PLA2G2A (0.46) | PLA2G2APLA2G10ALOX5PTPN1PTPN2 | |
| Oxalic Acid SCHEMBL29264741 | 0.76 | PLA2G2A (0.46) | PLA2G2APLA2G10PTPN1PTPN2PTPN6 | |
| SCHEMBL2227624 | 0.75 | PTPN1 (0.51) | ALOX5PTPN1PTPN2PTPN6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1862181-A2 | Combination therapy using an 11B-hydroxysteroid dehydrogenase type 1 inhibitor and an antihypertensive agent for the treatment of metabolic syndrome and related diseases and disorders | NOVO NORDISK A/S (DK) | 2007-12-05 | — | — | EP | claimed |
| CN-107286074-B | 3- hydroxyl iso-indoles -1- ketone derivatives and preparation method thereof | 厦门华厦学院 | 2019-08-20 | — | — | CN | disclosed |
| CN-107286074-A | Ketone derivatives of 3 hydroxyl iso-indoles 1 and preparation method thereof | 厦门华厦学院 | 2017-10-24 | — | — | CN | disclosed |
| EP-1862181-A2 | Combination therapy using an 11B-hydroxysteroid dehydrogenase type 1 inhibitor and an antihypertensive agent for the treatment of metabolic syndrome and related diseases and disorders | NOVO NORDISK A/S (DK) | 2007-12-05 | — | — | EP | disclosed |
| EP-1854487-A2 | Combinations of an 11-beta-hydroxysteroid dehaydrogenase type 1 inhibitor and a glucocorticoid receptor agonist | Novo Nordisk A/S (DK) | 2007-11-14 | — | — | EP | disclosed |