Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CTSV | O60911 | 1/20 | 0.45 |
| ▸ | PLAT | P00750 | 1/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.45 |
| ▸ | CTSH | P09668 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5547469 | 0.98 | LMNA (0.60) | LMNAMAPTALDH1A1MAPK1MEN1 | |
| SCHEMBL3477718 | 0.82 | EPHX2 (0.60) | LMNAMAPTALDH1A1MAPK1MEN1 | |
| SCHEMBL7793295 | 0.80 | LMNA (0.58) | LMNAMAPTALDH1A1MAPK1MEN1 | |
| SCHEMBL28645971 | 0.79 | NPC1 (0.57) | LMNAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL24949035 | 0.79 | SMN1; SMN2 (0.52) | LMNAMAPTALDH1A1MAPK1MEN1 | |
| SCHEMBL22732504 | 0.79 | SMN1; SMN2 (0.52) | LMNAMAPTALDH1A1MAPK1MEN1 | |
| SCHEMBL22792525 | 0.79 | SMN1; SMN2 (0.52) | LMNAMAPTALDH1A1MAPK1MEN1 | |
| SCHEMBL20926000 | 0.79 | SMN1; SMN2 (0.52) | LMNAMAPTALDH1A1MAPK1MEN1 | |
| SCHEMBL20892706 | 0.79 | SMN1; SMN2 (0.52) | LMNAMAPTALDH1A1MAPK1MEN1 | |
| SCHEMBL3091778 | 0.79 | SMN1; SMN2 (0.52) | LMNAMAPTALDH1A1MAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002000649-A9 | SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS | ASTRAZENECA AB (SE) | 2007-09-20 | — | — | WO | disclosed |
| CN-1496364-A | Substituted quinazoline derivatives and their use as inhibitors | — | 2004-05-12 | — | — | CN | disclosed |
| EP-1299381-A1 | SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS | AstraZeneca AB (SE) | 2003-04-09 | — | — | EP | disclosed |
| WO-2002000649-A1 | SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS | ASTRAZENECA AB (SE) | 2002-01-03 | — | — | WO | disclosed |