Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.56 |
| ▸ | F13A1 | P00488 | 2/20 | 0.56 |
| ▸ | CA2 | P00918 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.56 |
| ▸ | CA4 | P22748 | 2/20 | 0.56 |
| ▸ | CA6 | P23280 | 2/20 | 0.56 |
| ▸ | CA5A | P35218 | 2/20 | 0.56 |
| ▸ | THPO | P40225 | 2/20 | 0.56 |
| ▸ | CA7 | P43166 | 2/20 | 0.56 |
| ▸ | CA9 | Q16790 | 2/20 | 0.56 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.56 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | CA3 | P07451 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | MTOR | P42345 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL5552761 | 1.00 | CA12 (0.56) | CA12F13A1CA2CYP1A2ALOX15 | |
| Oxalic Acid SCHEMBL5556861 | 0.93 | CA12 (0.54) | CA12F13A1CA2CYP1A2ALOX15 | |
| Glycolic Acid SCHEMBL5552670 | 0.91 | ALOX15 (0.52) | CA12F13A1CA2CYP1A2ALOX15 | |
| Acetic Acid SCHEMBL5551560 | 0.91 | PAOX (0.55) | CA12F13A1CA2CYP1A2ALOX15 | |
| SCHEMBL263795 | 0.91 | CA12 (0.68) | CA12F13A1CA2CYP1A2ALOX15 | |
| Succinic Acid SCHEMBL5552836 | 0.90 | CYP2D6 (0.52) | CA12F13A1CA2CYP1A2ALOX15 | |
| SCHEMBL28950192 | 0.88 | CA12 (0.65) | CA12F13A1CA2CYP1A2ALOX15 | |
| SCHEMBL1036086 | 0.88 | CA12 (0.65) | CA12F13A1CA2CYP1A2ALOX15 | |
| SCHEMBL28778153 | 0.88 | CA12 (0.65) | CA12F13A1CA2CYP1A2ALOX15 | |
| Bromide SCHEMBL5552803 | 0.88 | CA12 (0.65) | CA12F13A1CA2CYP1A2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070185330-A1 | Liquids | THE UNIVERSITY OF YORK (GB) | 2007-08-09 | — | — | US | claimed |