Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | BLM | P54132 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | THRB | P10828 | 2/20 | 0.50 |
| ▸ | CA12 | O43570 | 2/20 | 0.50 |
| ▸ | F13A1 | P00488 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | CA4 | P22748 | 2/20 | 0.50 |
| ▸ | CA6 | P23280 | 2/20 | 0.50 |
| ▸ | CA5A | P35218 | 2/20 | 0.50 |
| ▸ | THPO | P40225 | 2/20 | 0.50 |
| ▸ | CA7 | P43166 | 2/20 | 0.50 |
| ▸ | CA9 | Q16790 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycolic Acid SCHEMBL5552670 | 0.90 | ALOX15 (0.52) | CYP2D6NFKB1ALOX15LMNACYP1A2 | |
| Bicarbonate SCHEMBL5551073 | 0.90 | CA12 (0.56) | ALOX15LMNACYP1A2KMT2ATSHR | |
| Bicarbonate SCHEMBL5552761 | 0.90 | CA12 (0.56) | ALOX15LMNACYP1A2KMT2ATSHR | |
| Butyric Acid SCHEMBL5551157 | 0.89 | PAOX (0.47) | CYP2D6NFKB1ALOX15LMNACYP1A2 | |
| Valeric Acid SCHEMBL5551421 | 0.88 | CYP2D6 (0.48) | CYP2D6NFKB1ALOX15LMNACYP1A2 | |
| Oxalic Acid SCHEMBL5556861 | 0.88 | CA12 (0.54) | ALOX15LMNACYP1A2KMT2ATSHR | |
| Spermine SCHEMBL27599902 | 0.87 | CYP1A2 (0.62) | CYP2D6NFKB1ALOX15LMNACYP1A2 | |
| Propionic Acid SCHEMBL5551771 | 0.86 | CA12 (0.48) | CYP2D6NFKB1ALOX15LMNACYP1A2 | |
| Hexanoate SCHEMBL5547209 | 0.86 | AKR1B1 (0.52) | CYP2D6NFKB1ALOX15LMNAKMT2A | |
| Acetic Acid SCHEMBL5551560 | 0.86 | PAOX (0.55) | ALOX15LMNACYP1A2KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070185330-A1 | Liquids | THE UNIVERSITY OF YORK (GB) | 2007-08-09 | — | — | US | claimed |