Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MME | P08473 | 2/20 | 0.33 |
| ▸ | ACE | P12821 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19592502 | 0.82 | AADAT (0.41) | TSHRAADATKMT2AMEN1HTT | |
| SCHEMBL30036591 | 0.82 | AADAT (0.41) | TSHRAADATKMT2AMEN1HTT | |
| SCHEMBL1562017 | 0.82 | AADAT (0.41) | TSHRAADATKMT2AMEN1HTT | |
| SCHEMBL18128200 | 0.80 | TSHR (0.54) | TSHRKMT2AMEN1HTTALDH1A1 | |
| SCHEMBL7345991 | 0.74 | MME (0.55) | TSHRKMT2AMEN1ALDH1A1L3MBTL1 | |
| SCHEMBL7345996 | 0.74 | MME (0.55) | TSHRKMT2AMEN1ALDH1A1L3MBTL1 | |
| SCHEMBL1561981 | 0.72 | TSHR (0.50) | TSHRKMT2AMEN1HTTALDH1A1 | |
| SCHEMBL5550815 | 0.71 | MME (0.50) | KMT2AMMEACE | |
| SCHEMBL1562578 | 0.70 | MEN1 (0.37) | TSHRKMT2AMEN1 | |
| SCHEMBL19224600 | 0.70 | RIPK1 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828151-A2 | MALONAMIDE DERIVATIVES AS INHIBITORS OF GAMMA-SECRETASE FOR THE TREATMENT OF ALZHEIMER'S DISEASE | F.HOFFMANN-LA ROCHE AG (CH) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006061136-A2 | MALONAMIDE DERIVATIVES AS INHIBITORS OF GAMMA-SECRETASE FOR THE TREATMENT OF ALZHEIMER’S DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2006-06-15 | — | — | WO | disclosed |