Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 6/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 2/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | BMX | P51813 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5551875 | 0.95 | MEN1 (0.50) | MEN1KMT2ATSHRRXFP1EGFR | |
| SCHEMBL5547801 | 0.88 | MEN1 (0.53) | MEN1KMT2ATSHRRXFP1ALDH1A1 | |
| SCHEMBL5551386 | 0.84 | KDM4E (0.47) | MEN1KMT2ATSHRKDM4EALDH1A1 | |
| SCHEMBL5547807 | 0.82 | EPHX2 (0.48) | MEN1KMT2ATSHRKDM4EALDH1A1 | |
| SCHEMBL5547969 | 0.80 | MEN1 (0.38) | MEN1KMT2ATSHRRXFP1EGFR | |
| SCHEMBL3282828 | 0.76 | SMN1; SMN2 (0.43) | MEN1KMT2ATSHR | |
| SCHEMBL3282830 | 0.76 | SMN1; SMN2 (0.43) | MEN1KMT2ATSHR | |
| SCHEMBL3282834 | 0.76 | SMN1; SMN2 (0.43) | MEN1KMT2ATSHR | |
| SCHEMBL5548685 | 0.74 | ABL1 (0.48) | MEN1KMT2AALDH1A1ABL1 | |
| SCHEMBL5782488 | 0.74 | DYRK1A (0.47) | MEN1KMT2ARXFP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1780211-A2 | Vanilloid receptor ligands and their use in treatments | Amgen Inc. (US) | 2007-05-02 | — | — | EP | disclosed |
| EP-1775295-A1 | Vanilloid receptor ligands and their use in treatments | Amgen Inc. (US) | 2007-04-18 | — | — | EP | disclosed |