Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | RHOA | P61586 | 10/20 | 0.47 |
| ▸ | STS | P08842 | 1/20 | 0.47 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | RHOC | P08134 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5547801 | 0.82 | MEN1 (0.53) | PTPN1MEN1ALDH1A1KMT2A | |
| SCHEMBL5548652 | 0.79 | TGFBR1 (0.53) | MAPTSTS | |
| SCHEMBL5551875 | 0.79 | MEN1 (0.50) | ABL1MEN1ALDH1A1KMT2A | |
| SCHEMBL16422638 | 0.78 | NPY5R (0.53) | ABL1RIN1MAPTRHOAPTPN2 | |
| SCHEMBL16238694 | 0.78 | NPY5R (0.53) | ABL1RIN1MAPTRHOAPTPN2 | |
| SCHEMBL5547807 | 0.78 | EPHX2 (0.48) | RHOASTSRHOCMEN1ALDH1A1 | |
| SCHEMBL5551386 | 0.78 | KDM4E (0.47) | MAPTRHOARHOCMEN1ALDH1A1 | |
| SCHEMBL24250378 | 0.78 | MAPT (0.59) | ABL1RIN1MAPTRHOAPTPN2 | |
| SCHEMBL193295 | 0.75 | RAB9A (0.65) | ABL1RIN1MAPTPTPN2PTPN1 | |
| SCHEMBL193294 | 0.75 | RAB9A (0.65) | ABL1RIN1MAPTPTPN2PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1780211-A2 | Vanilloid receptor ligands and their use in treatments | Amgen Inc. (US) | 2007-05-02 | — | — | EP | disclosed |
| EP-1775295-A1 | Vanilloid receptor ligands and their use in treatments | Amgen Inc. (US) | 2007-04-18 | — | — | EP | disclosed |