SCHEMBL5552196

SCHEMBL5552196

COC(=O)c1ccc(C)c(F)c1.[O-][S+](Cl)Cl

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 1/20 0.53
HDAC6 Q9UBN7 1/20 0.53
NOTUM Q6P988 1/20 0.50
CYP2C9 P11712 5/20 0.45
KCNQ3 O43525 2/20 0.45
KCNQ2 O43526 2/20 0.45
KCNE1 P15382 2/20 0.45
KCNQ1 P51787 2/20 0.45
CA12 O43570 1/20 0.45
CA1 P00915 1/20 0.45
CA2 P00918 1/20 0.45
CA7 P43166 1/20 0.45
XDH P47989 1/20 0.45
CA9 Q16790 1/20 0.45
CA14 Q9ULX7 1/20 0.45
KCNQ5 Q9NR82 1/20 0.45
ALDH1A1 P00352 3/20 0.44
TDP1 Q9NUW8 1/20 0.44
CYP1A2 P05177 1/20 0.44
CYP3A4 P08684 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1495863 0.90 HDAC1 (0.62) HDAC1HDAC6NOTUMCYP2C9KCNQ3
SCHEMBL3655388 0.86 HDAC1 (0.54) HDAC1HDAC6NOTUMCYP2C9KCNQ3
SCHEMBL22012866 0.81 CA1 (0.45) NOTUMCYP2C9CA12CA1CA2
SCHEMBL854583 0.76 NOTUM (0.54) NOTUMCYP2C9CA12CA1CA2
SCHEMBL29664708 0.76 CES2 (0.59) NOTUMCYP2C9CA12CA1CA2
SCHEMBL14012582 0.76 CES2 (0.59) NOTUMCYP2C9CA12CA1CA2
SCHEMBL383936 0.76 CES2 (0.59) NOTUMCYP2C9CA12CA1CA2
SCHEMBL12569420 0.75 HDAC1 (0.56) HDAC1HDAC6NOTUMKCNQ3KCNQ2
SCHEMBL29825107 0.75 ALDH1A1 (0.58) NOTUMCYP2C9KCNQ3KCNQ2KCNE1
SCHEMBL15968586 0.75 ALDH1A1 (0.58) NOTUMCYP2C9KCNQ3KCNQ2KCNE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1781661-A2 VASOPRESSIN V1A ANTAGONISTS Ferring B.V. (NL) 2007-05-09 EP disclosed
WO-2006021213-A2 VASOPRESSIN V1A ANTAGONISTS FERRING B.V. (NL) 2006-03-02 WO disclosed