Known targets — ChEMBL curated mechanism
CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8
The experimentally established mechanism targets of Phloroglucinol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.73 |
| ▸ | ACHE | P22303 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 5/20 | 0.50 |
| ▸ | CA9 | Q16790 | 5/20 | 0.50 |
| ▸ | CA2 | P00918 | 4/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.50 |
| ▸ | CA1 | P00915 | 4/20 | 0.50 |
| ▸ | CA7 | P43166 | 3/20 | 0.50 |
| ▸ | CA5A | P35218 | 3/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.44 |
| ▸ | FASN | P49327 | 1/20 | 0.43 |
| ▸ | NQO1 | P15559 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | BCR | P11274 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phloroglucinol SCHEMBL27792688 | 0.96 | BACE1 (0.67) | BACE1ACHECA12CA9CA2 | |
| Phloroglucinol SCHEMBL27549559 | 0.86 | BACE1 (0.80) | BACE1ACHECA12CA9CA2 | |
| Phloroglucinol SCHEMBL2889628 | 0.85 | BACE1 (1.00) | BACE1ACHECA12CA9CA2 | |
| Phloroglucinol SCHEMBL30542958 | 0.85 | — | — | |
| Phloroglucinol SCHEMBL26311 | 0.85 | — | — | |
| Orcinol SCHEMBL9579124 | 0.83 | ALDH1A1 (0.71) | BACE1ACHECA12CA9CA2 | |
| Phloroglucinol SCHEMBL20983097 | 0.80 | CA12 (0.65) | BACE1CA12CA9CA2CA14 | |
| Phloroglucinol SCHEMBL23346245 | 0.80 | BACE1 (0.89) | BACE1ACHECA12CA9CA2 | |
| Phloroglucinol SCHEMBL310716 | 0.80 | BACE1 (0.89) | BACE1ACHECA12CA9CA2 | |
| Phloroglucinol SCHEMBL5495237 | 0.80 | BACE1 (0.89) | BACE1ACHECA12CA9CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112646510-A | Preparation of novel flame retardant and application of novel flame retardant in flame-retardant adhesive | 山东大学 | 2021-04-13 | — | — | CN | claimed |
| CN-103072970-A | Spherical hollow mesoporous carbon shell and preparing method thereof | UNIV HEBEI SCIENCE & TECH | 2013-05-01 | — | — | CN | claimed |
| US-20070259979-A1 | ORGANIC AEROGELS REINFORCED WITH INORGANIC AEROGEL FILLERS | ASPEN AEROGELS, INC. (US) | 2007-11-08 | — | — | US | claimed |
| US-20240349404-A1 | APPARATUS AND METHOD FOR HEATING AT PYROLYTIC TEMPERATURES USING MICROWAVE RADIATION | ASPEN AEROGELS, INC. (US) | 2024-10-17 | — | — | US | disclosed |
| CN-118084668-A | Bibenzyl derivative and application thereof | 中南大学 | 2024-05-28 | — | — | CN | disclosed |
| WO-2023180971-A1 | APPARATUS AND METHOD FOR HEATING AT PYROLYTIC TEMPERATURES USING MICROWAVE RADIATION | ASPEN AEROGELS, INC. (US) | 2023-09-28 | — | — | WO | disclosed |
| CN-114045004-B | Phase-change composite thermal protection material and preparation method thereof | 航天特种材料及工艺技术研究所 | 2023-04-25 | — | — | CN | disclosed |
| CN-112646510-B | Preparation of flame retardant and application of flame retardant in flame-retardant adhesive | 山东大学 | 2022-03-25 | — | — | CN | disclosed |
| CN-113189090-A | Visual formaldehyde detection gel chip, portable formaldehyde detection device and preparation method thereof | 四川轻化工大学 | 2021-07-30 | — | — | CN | disclosed |
| CN-112646510-A | Preparation of novel flame retardant and application of novel flame retardant in flame-retardant adhesive | 山东大学 | 2021-04-13 | — | — | CN | disclosed |
| CN-107106628-B | Hair composition | 荷兰联合利华有限公司 | 2021-01-12 | — | — | CN | disclosed |
| CN-108484963-A | A kind of atmosphere pressure desiccation prepares the method for phenolic aldehyde aeroge and phenolic aldehyde aeroge obtained | 航天特种材料及工艺技术研究所 | 2018-09-04 | — | — | CN | disclosed |
| CN-105271212-B | A kind of graphene aerogel material and preparation method thereof | 航天特种材料及工艺技术研究所 | 2018-01-16 | — | — | CN | disclosed |
| CN-104446334-B | A kind of preparation method of inexpensive charcoal-aero gel heat-insulation composite material | 航天特种材料及工艺技术研究所 | 2017-08-04 | — | — | CN | disclosed |
| CN-103980103-B | PHENOLIC COMPOUND, EPOXY RESIN, EPOXY RESIN COMPOSITION, PREPREG, AND CURED PRODUCT THEREOF | 日本化药株式会社 | 2017-04-12 | — | — | CN | disclosed |
| CN-103072970-B | Spherical hollow mesoporous carbon shell and preparing method thereof | UNIV HEBEI SCIENCE & TECH | 2014-12-17 | — | — | CN | disclosed |
| CN-103072970-A | Spherical hollow mesoporous carbon shell and preparing method thereof | UNIV HEBEI SCIENCE & TECH | 2013-05-01 | — | — | CN | disclosed |
| US-20070259979-A1 | ORGANIC AEROGELS REINFORCED WITH INORGANIC AEROGEL FILLERS | ASPEN AEROGELS, INC. (US) | 2007-11-08 | — | — | US | disclosed |
| US-5037859-A | Cryogenic Inertial Confinement Fusion Target | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE UNITED STATES DEPARTMENT OF ENERGY (US) | 1991-08-06 | — | — | US | disclosed |
| US-4966919-A | FILLING OR COATING OF OPENCELL FOAM WITH CLOSED CELL OR OPEN CELL FOAM | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE UNITED STATES DEPARTMENT OF ENERGY (US) | 1990-10-30 | — | — | US | disclosed |