Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.44 |
| ▸ | KCNA5 | P22460 | 5/20 | 0.42 |
| ▸ | KCNE1 | P15382 | 2/20 | 0.42 |
| ▸ | OGA | O60502 | 6/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.41 |
| ▸ | GHSR | Q92847 | 3/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | MC4R | P32245 | 1/20 | 0.40 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.40 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.40 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.40 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.40 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.40 |
| ▸ | ACVR2B | Q13705 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5553128 | 0.98 | CYP2D6 (0.46) | CYP2D6KCNA5KCNE1OGACHRM2 | |
| SCHEMBL5550011 | 0.82 | CNR2 (0.47) | CYP2D6KCNA5KCNE1OGACHRM2 | |
| SCHEMBL5549440 | 0.82 | CNR2 (0.47) | CYP2D6KCNA5KCNE1OGACHRM2 | |
| SCHEMBL5550006 | 0.80 | CYP2D6 (0.46) | CYP2D6CHRM2LTA4HMC4RBMPR1B | |
| SCHEMBL5550009 | 0.80 | CYP2D6 (0.46) | CYP2D6CHRM2LTA4HMC4RBMPR1B | |
| SCHEMBL5553096 | 0.80 | CYP2D6 (0.46) | CYP2D6CHRM2LTA4HMC4RBMPR1B | |
| SCHEMBL5554053 | 0.78 | BMPR1B (0.42) | CYP2D6OGACHRM2LTA4HMC4R | |
| SCHEMBL6649009 | 0.77 | SCN9A (0.41) | OGACHRM2GHSRCYP3A4CYP2C9 | |
| SCHEMBL5549957 | 0.77 | OPRD1 (0.46) | CYP2D6KCNA5CHRM2CYP1A2CYP3A4 | |
| SCHEMBL5549489 | 0.77 | OPRD1 (0.46) | CYP2D6KCNA5CHRM2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756058-A1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | Pfizer Products Incorporated (US) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005105744-A1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. | 2005-11-10 | — | — | WO | disclosed |
| US-20050245543-A1 | Histamine-3 receptor antagonists | PFIZER INC | 2005-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245543-A1 | Histamine-3 receptor antagonists | HRH3, HRH4, HRH2 | CYP2D6 941/4885KCNA5 1873/4885KCNE1 1815/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.