Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 4/20 | 0.59 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.59 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | ACHE | P22303 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.53 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.53 |
| ▸ | CHRNA2 | Q15822 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.53 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.53 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.53 |
| ▸ | HTR3B | O95264 | 1/20 | 0.53 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.53 |
| ▸ | CHRNG | P07510 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10079075 | 0.90 | CHRNB2 (0.66) | CHRNB2CHRNA7CHRNA4ALDH1A1ACHE | |
| SCHEMBL12090442 | 0.88 | CHRNB2 (0.64) | CHRNB2CHRNA7CHRNA4ALDH1A1ACHE | |
| SCHEMBL2606079 | 0.84 | CHRNB2 (0.67) | CHRNB2CHRNA7CHRNA4ALDH1A1CHRNB4 | |
| SCHEMBL14235482 | 0.84 | CHRNB2 (0.67) | CHRNB2CHRNA7CHRNA4ALDH1A1CHRNB4 | |
| SCHEMBL5549987 | 0.84 | CHRNB2 (0.56) | CHRNB2CHRNA7CHRNA4ALDH1A1ACHE | |
| SCHEMBL6450243 | 0.84 | ALDH1A1 (0.73) | CHRNB2CHRNA7CHRNA4ALDH1A1ACHE | |
| SCHEMBL5555153 | 0.83 | CHRNB2 (0.55) | CHRNB2CHRNA7CHRNA4ALDH1A1ACHE | |
| SCHEMBL15784021 | 0.81 | CHRNB2 (0.56) | CHRNB2CHRNA7CHRNA4ALDH1A1ACHE | |
| SCHEMBL5553562 | 0.79 | ALDH1A1 (0.50) | CHRNB2CHRNA7CHRNA4ALDH1A1ACHE | |
| SCHEMBL13452380 | 0.78 | CHRNB2 (0.61) | CHRNB2CHRNA7CHRNA4CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756058-A1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | Pfizer Products Incorporated (US) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005105744-A1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. | 2005-11-10 | — | — | WO | disclosed |
| US-20050245543-A1 | Histamine-3 receptor antagonists | PFIZER INC | 2005-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245543-A1 | Histamine-3 receptor antagonists | HRH3, HRH4, HRH2 | CHRNB2 434/4885CHRNA7 161/4885CHRNA4 164/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.