Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 1/20 | 0.39 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.39 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.39 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | GCGR | P47871 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | GUSB | P08236 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | TYMS | P04818 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8963578 | 0.83 | NPC1 (0.45) | KDM4EGAA | |
| SCHEMBL5549123 | 0.80 | MAPK13 (0.44) | PI4KAPI4K2BPI4K2API4KBMAPK13 | |
| SCHEMBL5552730 | 0.77 | KDM4E (0.43) | PI4KAPI4K2BPI4K2API4KBKDM4E | |
| SCHEMBL5554927 | 0.73 | KDM4E (0.48) | KDM4ECYP1A2ALOX15 | |
| SCHEMBL3404703 | 0.70 | PI4KA (0.45) | PI4KAPI4K2BPI4K2API4KBMAPK13 | |
| SCHEMBL186872 | 0.69 | PI4KA (0.49) | PI4KAPI4K2BPI4K2API4KBMAPK13 | |
| SCHEMBL30516197 | 0.68 | TYMP (0.50) | PI4KAPI4K2BPI4K2API4KBMAPK13 | |
| SCHEMBL24317556 | 0.68 | PI4KA (0.47) | PI4KAPI4K2BPI4K2API4KBMAPK13 | |
| SCHEMBL415342 | 0.66 | KDM4E (0.46) | PI4KAPI4K2BPI4K2API4KBMAPK13 | |
| SCHEMBL27729265 | 0.66 | PI4KA (0.47) | PI4KAPI4K2BPI4K2API4KBMAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1848428-A2 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORPORATION (US) | 2007-10-31 | — | — | EP | disclosed |
| WO-2006089076-A2 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORPORATION (US) | 2006-08-24 | — | — | WO | disclosed |