Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 11/20 | 0.49 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.42 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.42 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.42 |
| ▸ | ZDHHC7 | Q9NXF8 | 1/20 | 0.41 |
| ▸ | BIRC2 | Q13490 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5199193 | 0.91 | ACHE (0.44) | ACHETAS1R3TAS1R1ZDHHC7CA1 | |
| SCHEMBL5199197 | 0.91 | ACHE (0.44) | ACHETAS1R3TAS1R1ZDHHC7CA1 | |
| SCHEMBL5970938 | 0.88 | ACHE (0.49) | ACHESIRT2SIRT1EPHX1 | |
| SCHEMBL8823889 | 0.87 | ERAP2 (0.46) | SIRT2SIRT1SIRT3TAS1R3TAS1R1 | |
| SCHEMBL11783967 | 0.87 | ERAP2 (0.46) | SIRT2SIRT1SIRT3TAS1R3TAS1R1 | |
| SCHEMBL10766995 | 0.87 | ERAP2 (0.46) | SIRT2SIRT1SIRT3TAS1R3TAS1R1 | |
| SCHEMBL6983765 | 0.85 | BIRC2 (0.43) | ACHESIRT2SIRT1SIRT3TAS1R3 | |
| SCHEMBL2344660 | 0.84 | EPHX1 (0.44) | ACHEEPHX1 | |
| SCHEMBL5198185 | 0.83 | ZDHHC7 (0.42) | ACHESIRT2SIRT1SIRT3TAS1R3 | |
| SCHEMBL4778608 | 0.83 | CA1 (0.41) | ACHETAS1R3TAS1R1ZDHHC7BIRC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1606255-A4 | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL MYERS SQUIBB CO (US) | 2007-02-07 | — | — | EP | disclosed |
| EP-1606255-A2 | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Bristol-Myers Squibb Company (US) | 2005-12-21 | — | — | EP | disclosed |
| WO-2004071460-A2 | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-08-26 | — | — | WO | disclosed |