Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | HTR1E | P28566 | 1/20 | 0.57 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.57 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | XBP1 | P17861 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 1/20 | 0.54 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28360244 | 0.81 | MEN1 (0.53) | MAPTALDH1A1EPHX2MEN1KMT2A | |
| SCHEMBL515008 | 0.79 | SMN1; SMN2 (0.68) | MAPTALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL28263497 | 0.78 | GAA (0.53) | MAPTALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL515007 | 0.78 | MAPT (0.62) | MAPTALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL19638388 | 0.77 | RXFP1 (0.73) | ALDH1A1LMNARXFP1EPHX2MEN1 | |
| SCHEMBL4312525 | 0.77 | MAPT (0.54) | MAPTALDH1A1LMNAEPHX2MEN1 | |
| SCHEMBL25389220 | 0.76 | RXFP1 (0.74) | MAPTALDH1A1LMNAHTR1ES1PR3 | |
| SCHEMBL2239100 | 0.76 | RXFP1 (0.74) | MAPTALDH1A1LMNAHTR1ES1PR3 | |
| SCHEMBL30042580 | 0.75 | RXFP1 (0.73) | MAPTALDH1A1LMNARXFP1MEN1 | |
| SCHEMBL1013325 | 0.75 | RXFP1 (0.73) | MAPTALDH1A1LMNARXFP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1620391-A4 | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL MYERS SQUIBB CO (US) | 2007-10-31 | — | — | EP | disclosed |
| EP-1620391-A2 | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Bristol-Myers Squibb Company (US) | 2006-02-01 | — | — | EP | disclosed |
| WO-2004098516-A2 | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-11-18 | — | — | WO | disclosed |