Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 3/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17669235 | 0.78 | KDM4E (0.37) | TRPA1KDM4EPOLBALDH1A1TSHR | |
| SCHEMBL11633545 | 0.76 | KDM4E (0.47) | KDM4EPOLBALDH1A1TSHRLMNA | |
| SCHEMBL283052 | 0.76 | KDM4E (0.47) | KDM4EPOLBALDH1A1TSHRLMNA | |
| SCHEMBL13759650 | 0.75 | CA1 (0.44) | KDM4EPOLBTSHRMAPK1HTT | |
| SCHEMBL8963799 | 0.75 | ALDH1A1 (0.42) | TRPA1ALDH1A1TSHRLMNAHPGD | |
| SCHEMBL15012421 | 0.74 | KDM4E (0.46) | KDM4EPOLBALDH1A1TSHRLMNA | |
| SCHEMBL11249114 | 0.74 | KDM4E (0.46) | KDM4EPOLBALDH1A1TSHRLMNA | |
| SCHEMBL19720286 | 0.74 | TRPA1 (0.43) | TRPA1ALDH1A1TSHRLMNAHPGD | |
| SCHEMBL5344530 | 0.74 | CA1 (0.41) | TRPA1KDM4EPOLBALDH1A1TSHR | |
| SCHEMBL27357817 | 0.72 | TRPA1 (0.43) | TRPA1ALDH1A1TSHRLMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1398315-B1 | Anti-inflammatory oxo-derivatives and hydroxy derivatives of pyrrolizines, and their pharmaceutical use | MERCKLE GMBH (DE) | 2007-08-08 | — | — | EP | disclosed |
| EP-1398315-A1 | Anti-inflammatory oxo-derivatives and hydroxy derivatives of pyrrolizines, and their pharmaceutical use | MERCKLE GMBH (DE) | 2004-03-17 | — | — | EP | disclosed |