Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K8 | P41279 | 3/20 | 0.51 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.42 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KMO | O15229 | 2/20 | 0.41 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.40 |
| ▸ | RORB | Q92753 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5555891 | 0.76 | MAP3K8 (0.76) | MAP3K8MAPK1MAP2K1MEN1POLB | |
| SCHEMBL3642157 | 0.72 | GPR35 (0.43) | BCL2L1TBXAS1MEN1KMT2AKMO | |
| SCHEMBL15697559 | 0.72 | BCL2L1 (0.54) | MAP3K8BCL2L1TBXAS1MEN1POLB | |
| SCHEMBL17053160 | 0.72 | KMT2A (0.47) | BCL2L1TBXAS1MEN1KMT2AKDM4E | |
| SCHEMBL20783838 | 0.69 | RAB9A (0.37) | RAB9AKMT2AKDM4EALDH1A1 | |
| SCHEMBL5125812 | 0.69 | KDM4E (0.65) | KMOACMSDRORBKDM4EALDH1A1 | |
| SCHEMBL22777733 | 0.69 | BCL2L1 (0.46) | MAP3K8BCL2L1MEN1POLBRAB9A | |
| SCHEMBL3141880 | 0.68 | KDM4E (0.57) | MAPK1RAB9AKMT2AKDM4EALDH1A1 | |
| SCHEMBL27738181 | 0.68 | RAB9A (0.58) | MAP3K8MAPK1MAP2K1MEN1POLB | |
| SCHEMBL5553871 | 0.68 | MAP3K8 (0.86) | MAP3K8MAPK1MAP2K1POLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753428-A2 | KINASE INHIBITORS AS THERAPEUTIC AGENTS | Abbott Laboratories (US) | 2007-02-21 | — | — | EP | disclosed |
| WO-2005110410-A2 | KINASE INHIBITORS AS THERAPEUTIC AGENTS | ABBOTT LABORATORIES (US) | 2005-11-24 | — | — | WO | disclosed |