Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | STS | P08842 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3180878 | 0.77 | USP30 (0.44) | USP30TSHRALOX15ATMGPR119 | |
| SCHEMBL25484607 | 0.75 | USP30 (0.44) | USP30TSHRALOX15STSATM | |
| SCHEMBL13342724 | 0.73 | USP30 (0.47) | USP30TSHRALOX15ATMGPR119 | |
| SCHEMBL13026389 | 0.72 | USP30 (0.46) | USP30TSHRALOX15ATMGPR119 | |
| SCHEMBL6823312 | 0.72 | USP30 (0.46) | USP30TSHRALOX15ATMGPR119 | |
| SCHEMBL8209292 | 0.71 | USP30 (0.69) | USP30TSHRALOX15ATMGPR119 | |
| SCHEMBL8218899 | 0.70 | GPR119 (0.48) | USP30TSHRALOX15ATMGPR119 | |
| SCHEMBL8212694 | 0.68 | TRPV1 (0.61) | USP30TSHRALOX15ATMGPR119 | |
| SCHEMBL8208288 | 0.68 | HDAC1 (0.47) | USP30TSHRALOX15STSATM | |
| SCHEMBL8200179 | 0.68 | TSHR (0.47) | USP30TSHRALOX15ATMGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799672-A2 | CGRP RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006041830-A2 | CGRP RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2006-04-20 | — | — | WO | disclosed |