Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.42 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 2/20 | 0.41 |
| ▸ | STS | P08842 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8224879 | 0.86 | HDAC1 (0.44) | HDAC1HDAC6KDM4EPKMTRPV1 | |
| SCHEMBL8218924 | 0.83 | HDAC1 (0.47) | HDAC1HDAC6KDM4EPKMTRPV1 | |
| SCHEMBL8227850 | 0.81 | HDAC1 (0.45) | HDAC1HDAC6KDM4EPKMTRPV1 | |
| SCHEMBL8218899 | 0.80 | GPR119 (0.48) | HDAC1HDAC6KDM4EPKMTRPV1 | |
| SCHEMBL8218912 | 0.80 | HDAC1 (0.46) | HDAC1HDAC6KDM4EPKMTRPV1 | |
| SCHEMBL8212694 | 0.78 | TRPV1 (0.61) | HDAC1HDAC6TRPV1TSHRALOX15 | |
| SCHEMBL8200179 | 0.78 | TSHR (0.47) | KDM4EPKMTRPV1TSHRALOX15 | |
| SCHEMBL8224883 | 0.77 | GPR119 (0.43) | HDAC1HDAC6GPR119 | |
| SCHEMBL14263479 | 0.76 | MEN1 (0.43) | HDAC1HDAC6STS | |
| SCHEMBL8227881 | 0.75 | HDAC1 (0.55) | HDAC1HDAC6KDM4EGPR119KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008033465-A1 | AZETIDINONE DERIVATIVES AND METHODS OF USE THEREOF | SCHERING CORPORATION (US) | 2008-03-20 | — | — | WO | disclosed |