Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 11/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 9/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.31 |
| ▸ | XDH | P47989 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10202140 | 0.89 | PIK3CD (0.39) | PIK3CAPIK3R1RAF1BRAFMTOR | |
| SCHEMBL5553112 | 0.88 | PIK3CA (0.39) | PIK3CAPIK3R1MTORPIK3CDPIK3CG | |
| SCHEMBL10202139 | 0.77 | USP2 (0.42) | PIK3CAPIK3R1MTORPIK3CDPIK3CG | |
| SCHEMBL5557327 | 0.72 | PIK3R1 (0.45) | PIK3CAPIK3R1MTORPIK3CDPIK3CG | |
| SCHEMBL26072359 | 0.71 | PIK3CA (0.50) | PIK3CAPIK3R1MTORPIK3CD | |
| SCHEMBL10092229 | 0.70 | PIK3CA (0.49) | PIK3CAPIK3R1MTORPIK3CD | |
| SCHEMBL7318610 | 0.69 | CTSK (0.43) | PIK3CAPIK3R1ALDH1A1 | |
| SCHEMBL5563275 | 0.69 | PIK3CA (0.44) | PIK3CAPIK3R1MTORPIK3CDPIK3CG | |
| SCHEMBL10092233 | 0.68 | PIK3CA (0.55) | PIK3CAPIK3R1MTORALDH1A1 | |
| SCHEMBL5560237 | 0.68 | PIK3CA (0.64) | PIK3CAPIK3R1MTORPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012052730-A1 | USE OF PI3K INIBITORS FOR THE TREATMENT OF OBESITY, STEATOSIS AND AGEING | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-04-26 | — | — | WO | disclosed |
| WO-2012052745-A1 | COMBINATIONS OF PI3K INHIBITORS WITH A SECOND ANTI -TUMOR AGENT | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-04-26 | — | — | WO | disclosed |
| EP-2444084-A1 | Use of PI3K inibitors for the treatment of obesity | Centro Nacional de Investigaciones Oncológicas (CNIO) (ES) | 2012-04-25 | — | — | EP | disclosed |
| WO-2010119264-A1 | IMIDAZOPYRAZINES FOR USE AS KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCÓLOGICAS (CNIO) (ES) | 2010-10-21 | — | — | WO | disclosed |