Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 3/20 | 0.49 |
| ▸ | DRD2 known ✓ | P14416 | 3/20 | 0.42 |
| ▸ | DRD4 known ✓ | P21917 | 2/20 | 0.42 |
| ▸ | HTR2A known ✓ | P28223 | 2/20 | 0.41 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.49 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.49 |
| ▸ | DRD1 | P21728 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL5558647 | 1.00 | HRH1 (0.49) | HRH1CHRM1PAK1DRD2DRD4 | |
| SCHEMBL14511275 | 0.93 | CHRM1 (0.56) | HRH1CHRM1PAK1DRD2DRD4 | |
| Succinic Acid SCHEMBL4844157 | 0.90 | HRH1 (0.49) | HRH1CHRM1PAK1DRD2DRD4 | |
| Succinic Acid SCHEMBL4844168 | 0.90 | HRH1 (0.49) | HRH1CHRM1PAK1DRD2DRD4 | |
| Succinic Acid SCHEMBL5562653 | 0.90 | CHRM1 (0.47) | HRH1CHRM1PAK1 | |
| Succinic Acid SCHEMBL5562655 | 0.90 | CHRM1 (0.47) | HRH1CHRM1PAK1 | |
| Succinic Acid SCHEMBL5558777 | 0.86 | HRH1 (0.44) | HRH1CHRM1PAK1DRD2DRD4 | |
| Succinic Acid SCHEMBL5558774 | 0.86 | HRH1 (0.44) | HRH1CHRM1PAK1DRD2DRD4 | |
| SCHEMBL14156704 | 0.83 | CHRM1 (0.56) | HRH1CHRM1PAK1DRD2DRD4 | |
| SCHEMBL5557093 | 0.82 | CHRM1 (0.53) | HRH1CHRM1PAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1492794-B1 | PIPERAZINE SUBSTITUTED ARYL BENZODIAZEPINES AND THEIR USE AS DOPAMINE RECEPTOR ANTAGONISTS FOR THE TREATMENT OF PSYCHOTIC DISORDERS | LILLY CO ELI (US) | 2007-12-12 | — | — | EP | disclosed |