Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 5/20 | 0.44 |
| ▸ | DRD2 known ✓ | P14416 | 3/20 | 0.39 |
| ▸ | DRD4 known ✓ | P21917 | 2/20 | 0.39 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.38 |
| ▸ | HTR2A known ✓ | P28223 | 4/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.44 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | CTNNB1 | P35222 | 3/20 | 0.36 |
| ▸ | TCF7L2 | Q9NQB0 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL5558777 | 1.00 | HRH1 (0.44) | HRH1CHRM1PAK1DRD2DRD4 | |
| SCHEMBL5559494 | 0.93 | CHRM1 (0.50) | HRH1CHRM1PAK1DRD2DRD4 | |
| SCHEMBL5559499 | 0.93 | CHRM1 (0.50) | HRH1CHRM1PAK1DRD2DRD4 | |
| SCHEMBL5559491 | 0.93 | CHRM1 (0.50) | HRH1CHRM1PAK1DRD2DRD4 | |
| Succinic Acid SCHEMBL5563931 | 0.90 | CHRM1 (0.42) | HRH1CHRM1PAK1 | |
| Succinic Acid SCHEMBL5563925 | 0.90 | CHRM1 (0.42) | HRH1CHRM1PAK1 | |
| Succinic Acid SCHEMBL4835777 | 0.90 | HRH1 (0.44) | HRH1CHRM1PAK1DRD2DRD4 | |
| Succinic Acid SCHEMBL4835784 | 0.90 | HRH1 (0.44) | HRH1CHRM1PAK1DRD2DRD4 | |
| Succinic Acid SCHEMBL5558647 | 0.86 | HRH1 (0.49) | HRH1CHRM1PAK1DRD2DRD4 | |
| Succinic Acid SCHEMBL5558653 | 0.86 | HRH1 (0.49) | HRH1CHRM1PAK1DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7214673-B2 | For therapy of psychosis and bipolar disorder | ELI LILLY AND COMPANY (US) | 2007-05-08 | — | — | US | disclosed |
| US-20050203296-A1 | For therapy of psychosis and bipolar disorder | ELI LILLY AND COMPANY | 2005-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050203296-A1 | For therapy of psychosis and bipolar disorder | DRD4, AFF4, DRD2 | HRH1 201/4885DRD2 3/4885DRD4 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.