Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 13/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 12/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 10/20 | 0.68 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | TACR3 | P29371 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL556954 | 1.00 | REN (0.68) | RENKCNH2CYP3A4GPR119IDO1 | |
| SCHEMBL557232 | 0.87 | REN (0.63) | RENKCNH2CYP3A4NTRK1USP30 | |
| SCHEMBL556563 | 0.83 | REN (0.47) | RENKCNH2CYP3A4 | |
| SCHEMBL556978 | 0.82 | REN (0.72) | RENKCNH2CYP3A4IDO1 | |
| SCHEMBL557655 | 0.81 | REN (1.00) | RENKCNH2CYP3A4 | |
| SCHEMBL557233 | 0.80 | REN (0.64) | RENKCNH2CYP3A4NTRK1 | |
| SCHEMBL556955 | 0.80 | REN (0.64) | RENKCNH2CYP3A4NTRK1 | |
| SCHEMBL555873 | 0.80 | REN (0.64) | RENKCNH2CYP3A4NTRK1 | |
| SCHEMBL556501 | 0.78 | REN (0.61) | RENKCNH2CYP3A4IDO1USP30 | |
| SCHEMBL556391 | 0.77 | REN (0.77) | RENKCNH2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120035214-A1 | RENIN INHIBITORS | MERCK CANADA INC. (CA) | 2012-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035214-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | REN 1/4885KCNH2 1198/4885CYP3A4 766/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.