Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 5/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5558739 | 0.86 | AKR1C3 (0.57) | AKR1C3AKR1C2LMNASMN1; SMN2NPSR1 | |
| SCHEMBL5554613 | 0.86 | AKR1C3 (0.39) | AKR1C3AKR1C2LMNANPSR1KDM4E | |
| SCHEMBL6425939 | 0.85 | PLA2G2A (0.47) | AKR1C3AKR1C2LMNASMN1; SMN2NPSR1 | |
| SCHEMBL5553916 | 0.84 | AKR1C3 (0.40) | AKR1C3AKR1C2LMNANPSR1KDM4E | |
| SCHEMBL5801149 | 0.84 | AKR1C3 (0.43) | AKR1C3AKR1C2LMNASMN1; SMN2NPSR1 | |
| SCHEMBL5553962 | 0.83 | AKR1C3 (0.39) | AKR1C3AKR1C2LMNANPSR1KDM4E | |
| SCHEMBL6424911 | 0.83 | AKR1C3 (0.45) | AKR1C3AKR1C2LMNASMN1; SMN2NPSR1 | |
| SCHEMBL5558847 | 0.82 | AKR1C3 (0.42) | AKR1C3AKR1C2LMNASMN1; SMN2NPSR1 | |
| SCHEMBL5559371 | 0.82 | PTGS2 (0.46) | AKR1C3AKR1C2SMN1; SMN2NPSR1KDM4E | |
| SCHEMBL6465001 | 0.82 | AKR1C3 (0.46) | AKR1C3AKR1C2LMNASMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1643961-A4 | COX-2 AND FAAH INHIBITORS | MICROBIA INC (US) | 2007-09-12 | — | — | EP | disclosed |
| EP-1643961-A2 | COX-2 AND FAAH INHIBITORS | Microbia, Inc. (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005002525-A2 | COX-2 AND FAAH INHIBITORS | MICROBIA, INC. (US) | 2005-01-13 | — | — | WO | disclosed |